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Titolo:
Antidiabetogenic action of glucagon-like peptide-1 related to administration relative to meal intake in subjects with type 2 diabetes
Autore:
Gutniak, MK; Svartberg, J; Hellstrom, PM; Holst, JJ; Adner, N; Ahren, B;
Indirizzi:
Univ Lund, BMC, Dept Med, SE-22184 Lund, Sweden Univ Lund Lund Sweden SE-22184 und, BMC, Dept Med, SE-22184 Lund, Sweden Soder Sjukhuset, Dept Med, S-10064 Stockholm, Sweden Soder Sjukhuset Stockholm Sweden S-10064 Med, S-10064 Stockholm, Sweden Univ Tromso Hosp, Dept Med, N-9038 Tromso, Norway Univ Tromso Hosp Tromso Norway N-9038 p, Dept Med, N-9038 Tromso, Norway Karolinska Hosp, Dept Gastroenterol & Hepatol, S-10401 Stockholm, Sweden Karolinska Hosp Stockholm Sweden S-10401 atol, S-10401 Stockholm, Sweden Univ Copenhagen, Panum Inst, Dept Med Physiol, DK-2200 Copenhagen N, Denmark Univ Copenhagen Copenhagen Denmark N siol, DK-2200 Copenhagen N, Denmark
Titolo Testata:
JOURNAL OF INTERNAL MEDICINE
fascicolo: 1, volume: 250, anno: 2001,
pagine: 81 - 87
SICI:
0954-6820(200107)250:1<81:AAOGPR>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
FASTING HYPERGLYCEMIA; POLYETHYLENE-GLYCOL; PROMOTES SATIETY; ENERGY-INTAKE; OBESE MEN; INSULIN; MELLITUS; GLP-1; HUMANS; INCRETIN;
Keywords:
gastric emptying; GLP-1; standard meal; type 2 diabetes;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Ahren, B Univ Lund, BMC, Dept Med, B11, SE-22184 Lund, Sweden Univ Lund B11 Lund Sweden SE-22184 d, B11, SE-22184 Lund, Sweden
Citazione:
M.K. Gutniak et al., "Antidiabetogenic action of glucagon-like peptide-1 related to administration relative to meal intake in subjects with type 2 diabetes", J INTERN M, 250(1), 2001, pp. 81-87

Abstract

Objective, To establish the antidiabetogenic effect of glucagon-like peptide-1 (GLP-1) when differently administered relative to meal intake in subjects with type 2 diabetes,Design, The study was a placebo-controlled comparison with random assignment to treatment sequence. A 3-h stepwise infusion of GLP-1 (17 nmol) was started either at the onset of a standard meal (550 kCal) (A) or at 30 min (B) or 60 min (C) after the start of the meal. Setting, The study was conducted at a university hospital. Subjects, Eight patients with type 2 diabetes (four women and four men), age 62 +/- 3.9 years (range 47-74 years), weight 79.8 +/- 5.4 kg (range 62-104 kg), BMI 26.2 +/- 1.3 kg m(-2) (range 21-31 kg m(-2)), diabetes duration10.5 +/- 2.0 years (range 3-19 years) and HbA1c levels 6.1 +/- 0.3% (range4.7-7.7%) participated in the study. All patients were treated with oral sulphonylureas. Results. Glucagon-like peptide-1 significantly lowered postprandial glycaemia by a similar degree in all three situations versus the control meal(P <0.05). Postprandial insulin levels were not different in the four experimental series, whereas the postprandial glucagon levels were significantly lowered by GLP-1 in (A) and (B) (P < 0.03) but not in (C). Gastric emptying, as determined by the paracetamol test, was retarded by GLP-1 only in (A) (P< 0.01), but not affected in (B) or (C). Conclusions. GLP-1 reduced postprandial hyperglycaemia in subjects with type 2 diabetes regardless of administration at the onset of meal intake or at 30 or 60 min after start of meal intake, although the mechanism of the antidiabetogenic action of GLP-1 depended on administration versus meal intake. Thus, when administered at the start of a meal, GLP-1 was antidiabetogenic mainly through retarding gastric emptying, whereas when given at 30 or 60 min after meal ingestion, changes in islet hormone secretion seem to be predominant.

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Documento generato il 01/12/20 alle ore 08:21:14