Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Genetic analysis of a local recurrent tumor after colonic polypectomy
Autore:
Takada, M; Fukui, H; Kashiwagi, R; Fujita, M; Kusaka, T; Ono, Y; Kuroda, Y; Kawamata, H; Chiba, T; Fujimori, T;
Indirizzi:
Kobe Univ, Sch Med, Dept Surg 1, Kobe, Hyogo 650, Japan Kobe Univ Kobe Hyogo Japan 650 h Med, Dept Surg 1, Kobe, Hyogo 650, Japan
Titolo Testata:
JOURNAL OF GASTROENTEROLOGY
fascicolo: 7, volume: 36, anno: 2001,
pagine: 500 - 503
SICI:
0944-1174(200107)36:7<500:GAOALR>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
P53 MUTATIONS; CARCINOMAS; POLYPS; CANCER; PROLIFERATION; COLONOSCOPY; EXPRESSION; ADENOMAS;
Keywords:
p53; polypectomy; colon; recurrence; sequencing;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
14
Recensione:
Indirizzi per estratti:
Indirizzo: Fujimori, T Dokkyo Univ, Sch Med, Dept Pathol, 880 Kitakobayashi, Mibu, Tochigi 3210293, Japan Dokkyo Univ 880 Kitakobayashi Mibu Tochigi Japan 3210293 Japan
Citazione:
M. Takada et al., "Genetic analysis of a local recurrent tumor after colonic polypectomy", J GASTRO, 36(7), 2001, pp. 500-503

Abstract

After polypectomy, the cut end of the polyp is usually examined by light microscopy to assess the risk of recurrent cancer. Here, we report a recurrent tumor that appeared in the colon 6 years after polypectomy, although cancer cells were not observed in hematoxylin and eosin-stained sections of the cut end of the primary polyp. Retrospectively, the primary polyp and the recurrent tumor were analyzed for mutations of the p53 gene. We detected p53 mutations in the primary polyp, even in the cut end of the polyp. The same set of two p53 mutations was detected in the recurrent tumor. These observations indicate a common origin of the primary tumor and the recurrent tumor. We conclude that it is important to analyze p53 mutations in colonic polyps, especially when the cut end of the polyp is difficult to evaluate histologically, in order to predict recurrence.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/04/20 alle ore 09:14:35