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Titolo:
Measurement of circulating biliary glycoprotein (CD66a) in liver diseases
Autore:
Kondo, Y; Hinoda, Y; Akashi, H; Sakamoto, H; Itoh, F; Hirata, K; Kuroki, M; Imai, K;
Indirizzi:
Sapporo Med Univ, Dept Internal Med 1, Sapporo, Hokkaido, Japan Sapporo Med Univ Sapporo Hokkaido Japan Med 1, Sapporo, Hokkaido, Japan
Titolo Testata:
JOURNAL OF GASTROENTEROLOGY
fascicolo: 7, volume: 36, anno: 2001,
pagine: 470 - 475
SICI:
0944-1174(200107)36:7<470:MOCBG(>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELL-ADHESION MOLECULE; CARCINOEMBRYONIC ANTIGEN FAMILY; CROSS-REACTING ANTIGEN; C-CAM; HEPATOCELLULAR CARCINOMAS; TYROSINE PHOSPHORYLATION; COLORECTAL CARCINOMAS; COLON-CANCER; EXPRESSION; ASSOCIATION;
Keywords:
biliary glycoprotein; CD66a; carcinoembryonic antigen; gamma-glutamyl transpeptidase;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Hinoda, Y Yamaguchi Univ, Sch Med, Dept Clin Lab Sci, 1-1-1 Minami Kogushi, Ube, Yamaguchi 7558505, Japan Yamaguchi Univ 1-1-1 Minami Kogushi Ube Yamaguchi Japan 7558505
Citazione:
Y. Kondo et al., "Measurement of circulating biliary glycoprotein (CD66a) in liver diseases", J GASTRO, 36(7), 2001, pp. 470-475

Abstract

Purpose. Biliary glycoprotein (BGP), a member of the carcinoembryonic antigen (CEA) gene family, is produced by hepatocytes, and is suggested to function as a cell adhesion molecule, mouse hepatitis virus receptor, and tumorsuppressor. Our aim was to establish an enzyme immunoassay for circulatingBGP and to study its significance in liver diseases. Methods. For enzyme immunoassay, a monoclonal antibody (mAb), TS135, which recognizes BGP was used as a catcher, and biotin-labeled polyclonal anti-CEA antibodies were used as a tracer. Seventy-six serum specimens obtained from patients with various liver diseases were submitted to the assay. Results. The incidence of positivity for antigen TS135 in the serum samples of the 76 patients was 57.9%. The most significant correlation among conventional liver function tests was found between antigen TS135 and gamma -glutamyl transpeptidase (I-GTP). However; among the 56 patients whose serum antigen TS135 and gamma -GTP levels could be measured simultaneously, 5 were antigen TS135-positive and gamma -GTP-negative (8.9%) and 6 were antigen TS135-negative and gamma -GTP-positive (10.7%). The increased serum level of antigen TS135 in 6 cholangiocellular carcinoma (CCC) patients led us to the immunohistochemical study of CCC; in which 8 of the 8 tissue specimens tested were positive for mAb TS135, indicating the production of the antigen from CCCs. Conclusions. Thispreliminary study suggests that the circulating antigen TS135 level correlates with gamma -GTP in liver diseases, but that TS135 may also have a unique significance, different from that of gamma -GTP, as a liver function test.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 12:44:55