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Titolo:
Arterial thrombus dissolution in vivo using a transducer-tipped, high-frequency ultrasound catheter and local low-dose urokinase delivery
Autore:
Atar, S; Luo, H; Nagai, T; Sahm, RA; Fishbein, MC; Siegel, RJ;
Indirizzi:
Cedars Sinai Med Ctr, Div Cardiol, Cardiac Noninvas Lab, Los Angeles, CA 90048 USA Cedars Sinai Med Ctr Los Angeles CA USA 90048 , Los Angeles, CA 90048 USA Univ Calif Los Angeles, Sch Med, Los Angeles, CA USA Univ Calif Los Angeles Los Angeles CA USA , Sch Med, Los Angeles, CA USA EKOS Corp, Bothell, WA USA EKOS Corp Bothell WA USAEKOS Corp, Bothell, WA USA
Titolo Testata:
JOURNAL OF ENDOVASCULAR THERAPY
fascicolo: 3, volume: 8, anno: 2001,
pagine: 282 - 290
SICI:
1526-6028(200106)8:3<282:ATDIVU>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
TISSUE-PLASMINOGEN-ACTIVATOR; ACUTE MYOCARDIAL-INFARCTION; PERIPHERAL ARTERIAL; IN-VITRO; THROMBOLYSIS; INVITRO; FIBRINOLYSIS; CLOT; ANGIOSCOPY; OCCLUSIONS;
Keywords:
thrombolysis; superficial femoral artery; canine model; angiography; angioscopy; histopathology;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Siegel, RJ Cedars Sinai Med Ctr, Div Cardiol, Cardiac Noninvas Lab, 8700 Beverly Blvd,Room 5335 N Tower, Los Angeles, CA 90048 USA Cedars Sinai Med Ctr 8700 Beverly Blvd,Room 5335 N Tower Los Angeles CA USA 90048
Citazione:
S. Atar et al., "Arterial thrombus dissolution in vivo using a transducer-tipped, high-frequency ultrasound catheter and local low-dose urokinase delivery", J ENDOVAS T, 8(3), 2001, pp. 282-290

Abstract

Purpose: To examine the hypothesis that a transducer-tipped high-frequencyultrasound drug-delivery catheter may augment the thrombolytic effects of locally delivered low-dose urokinase and result in improved recanalization rates and reduced residual thrombotic burden. Methods: Thrombi were induced in situ bilaterally in 5- to 6-cm-long segments of the superficial femoral arteries in 9 dogs by intraluminal thermal damage and injection of thrombin. A transducer-tipped high-frequency local drug-delivery catheter was applied at 1.1 MHz and 0.6 W for 60 minutes to one superficial femoral artery segment, and an identical catheter with an inactivated ultrasound transducer was used to treat the contralateral control segment. Urokinase (5000 IU/kg) was delivered bilaterally into the thrombi during the treatment interval. Results: Angiography documented TIMI grade 2 or 3 flow in 9 (100%) segments in the ultrasound-treated group versus 6 (67%) of the controls (no ultrasound) (p = 0.058). Angiographically detected distal embolization was found in 2 ultrasound-treated segments compared with 5 controls (p = 0.02). Protruding or occlusive thrombi were seen angioscopically in 8 (89%) control segments but in only 1 (11%) of the ultrasound-treated arteries (p < 0.001). By histopathology, 7 (78%) segments in the control group had occlusive thrombi, whereas only 3 nonocclusive thrombi were found in the ultrasound-treatment group (p < 0.001). Conclusions: Catheter-delivered high-frequency ultrasound and local low-dose urokinase infusion is efficacious for the treatment of acute thrombotic occlusions as evaluated by angiography, angioscopy, and histopathology.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 06:02:30