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Titolo:
Polymorphisms in the RAGE gene influence susceptibility to diabetes-associated microvascular dermatoses in NIDDM
Autore:
Kankova, K; Zahejsky, J; Marova, I; Muzik, J; Kuhrova, V; Blazkova, M; Znojil, V; Beranek, M; Vacha, J;
Indirizzi:
Masaryk Univ, Fac Med, Dept Pathophysiol, Brno 66243, Czech Republic Masaryk Univ Brno Czech Republic 66243 ysiol, Brno 66243, Czech Republic
Titolo Testata:
JOURNAL OF DIABETES AND ITS COMPLICATIONS
fascicolo: 4, volume: 15, anno: 2001,
pagine: 185 - 192
SICI:
1056-8727(200107/08)15:4<185:PITRGI>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLYCOSYLATION END-PRODUCTS; STRATUM-CORNEUM; GLYCATION; COMPLICATIONS; MELLITUS; SKIN; RECEPTOR; MICROANGIOPATHY; PROTEINS; COLLAGEN;
Keywords:
genetic polymorphism; RAGE; diabetic microangiopathy; diabetic complications; diabetes-associated dermatoses;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Kankova, K Masaryk Univ, Fac Med, Dept Pathophysiol, Komenskeho Nam 2, Brno 66243, Czech Republic Masaryk Univ Komenskeho Nam 2 Brno Czech Republic 66243 public
Citazione:
K. Kankova et al., "Polymorphisms in the RAGE gene influence susceptibility to diabetes-associated microvascular dermatoses in NIDDM", J DIABET C, 15(4), 2001, pp. 185-192

Abstract

To examine genetic polymorphism in the complete sequence of the Receptor of Advanced Glycation End products (RAGE) gene and its possible associationswith diabetes-associated microvascular dermatoses (DAMD). Further, to analyze the distribution of individual genotype combinations on the particular polymorphic loci in the RAGE gene. A part of the RACE gene spanning a region from - 4 to 3334 bp was analyzed on a set of 45 subjects with non-insulindependent diabetes mellitus (NIDDM) and parallel DAMD by means of PCR withsubsequent heteroduplex and single-strand conformation polymorphism (SSCP)analyses. Allele frequencies and genotype combinations of novel common polymorphisms were determined in an associations study comprising four groups of subjects (n = 390). Fourteen novel polymorphisms (R77C, V89V. 718G/T, 1704G/T, 1727A1728ins, H305Q, S307C, 2117A/G, 2184A/G, 2245G/A, 2249A/G, 2741G/A, and 3089ACdel) and one described previously (G82S) were identified. Significant association with microvascular dermatoses (MD) irrespective of NIDDM were found for exon mutation 82S (P = .004, after a correction for the number of comparisons P-corr < .05) and marginally significant for intron variant 1704T (P = .032, P-corr < .05). Calculated odds ratios for 82S and 1704T were 4.73 (95% CI, 1.51 to 14.77) and 1.73 (95% CI, 0.93 to 3.22), respectively. Certain individual genotype combinations of G82S, 1704G/T: and 2184A/G were significantly associated with the presence of MD ( P = .00647) both in diabetic and non-diabetic study populations. The Two novel polymorphisms (1704G/T and 2184A/GG) together with the C82S were shown to influencethe susceptibility to MD independent of diabetes itself. (C) 2001 ElsevierScience Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/04/20 alle ore 23:59:04