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Titolo:
CD45RA+immunophenotype in mycosis fungoides: clinical, histological and immunophenotypical features in 22 patients
Autore:
Fierro, MT; Novelli, M; Savoia, P; Cambleri, I; Quaglino, P; Osella-Abate, S; Bernengo, MG;
Indirizzi:
Univ Turin, Sect Dermatol 1, Dept Med & Surg Specialities, I-10126 Turin, Italy Univ Turin Turin Italy I-10126 & Surg Specialities, I-10126 Turin, Italy
Titolo Testata:
JOURNAL OF CUTANEOUS PATHOLOGY
fascicolo: 7, volume: 28, anno: 2001,
pagine: 356 - 362
SICI:
0303-6987(200108)28:7<356:CIMFCH>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
T-CELL LYMPHOMA; DISSEMINATED PAGETOID RETICULOSIS; HUMAN LYMPHOCYTES-T; CUTANEOUS LYMPHOMAS; ADHESION MOLECULE; SEZARY-SYNDROME; CD45R SUBSETS; SKIN-LESIONS; MEMORY; EXPRESSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Bernengo, MG Univ Turin, Sect Dermatol 1, Dept Med & Surg Specialities, Via Cherasco 23, I-10126 Turin, Italy Univ Turin Via Cherasco 23 Turin ItalyI-10126 Turin, Italy
Citazione:
M.T. Fierro et al., "CD45RA+immunophenotype in mycosis fungoides: clinical, histological and immunophenotypical features in 22 patients", J CUT PATH, 28(7), 2001, pp. 356-362

Abstract

Background: Mycosis fungoides (MF) is a cutaneous T-cell lymphoma (CTCL) usually characterized by a T-helper memory phenotype (CD3+, CD4+, CD8-, CD45R0+). Aberrant phenotypes are more commonly seen in the tumor stages. CD45RA expression has so far been documented in only a few cases of CD8+ or TCR gamma delta+ CTCL and in some pagetoid reticulosis cases. Methods: Two hundred and fifteen MF patients were immunophenotyped in our laboratory between January 1992 and June 2000 and 22 cases of CD45RA+ MF (8.7%) were identified by immunohistochemical analysis. Results: The majority of these CD45RA+ patients (20/22) showed a patch-plaque stage disease and an indolent clinical course, as expected in early-stage ME The remaining 2 patients presented with stage IIB and IVA MF, and were characterized by an aggressive clinical course, with systemic spread. Theimmunohistochemical analysis revealed that CD45RA+ neoplastic cells belonged to the memory compartment, displaying a CD62L-, CD11a+, CD29+ phenotype. Most patients showed aberrant phenotypes, with a loss of T-cell lineage markers and expression of cytotoxic molecules or gamma-delta chain of the T-cell receptor. Conclusions: Our data show that CD45RA+ MF is a rare variant of CTCL and shares with the classic MF cases both the clinical features and disease course, even if it is characterized by a higher incidence of immunopathologicalabnormalities.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/11/20 alle ore 14:33:53