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Titolo:
pH compartmented w/o/w multiple emulsion: a diffusion study
Autore:
Tedajo, GM; Seiller, M; Prognon, P; Grossiord, JL;
Indirizzi:
CNRS, Lab Physicochim Pharmacotech & Biopharm, UMR 8612, Ctr Etud Pharmaceut, F-92296 Chatenay Malabry, France CNRS Chatenay Malabry France F-92296t, F-92296 Chatenay Malabry, France Ctr Etud Pharmaceut, Chim Analyt Lab, F-92296 Chatenay Malabry, France CtrEtud Pharmaceut Chatenay Malabry France F-92296 enay Malabry, France
Titolo Testata:
JOURNAL OF CONTROLLED RELEASE
fascicolo: 1-2, volume: 75, anno: 2001,
pagine: 45 - 53
SICI:
0168-3659(20010710)75:1-2<45:PCWMEA>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
RELEASE; PHASE; SURFACTANT; EXTRACTION; TRANSPORT; MEMBRANES; ACIDS;
Keywords:
w/o/w emulsions; transport; diffusion; release;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Grossiord, JL CNRS, Lab Physicochim Pharmacotech & Biopharm, UMR 8612, CtrEtud Pharmaceut, 5 Rue JB Clement, F-92296 Chatenay Malabry, France CNRS 5Rue JB Clement Chatenay Malabry France F-92296 rance
Citazione:
G.M. Tedajo et al., "pH compartmented w/o/w multiple emulsion: a diffusion study", J CONTR REL, 75(1-2), 2001, pp. 45-53

Abstract

In order to develop w/o/w emulsions characterized by two separate aqueous phases of different pH, a preliminary study was carried out to obtain a better insight into the possible diffusion processes taking place between an inner acidic aqueous phase and an external phase of higher pH (pH approximate to6). In fact, such systems could be of great interest for pharmaceuticaluse. For this purpose, a model emulsion was formulated. The study of pH and conductivity showed that acidic species transport take place between the two aqueous compartments. The three main release mechanisms that might be responsible for this passage across the oil phase were investigated: breakdown of oil globules, facilitated transport by surfactant micelles across theoil phase or by Fickian diffusion. It appears that this last mechanism wasinvolved. In order to control this diffusion process, an alkaline species,octadecylamine was introduced in the oil phase. This compound could form an ion pair with the lactate ion at the interface of the external aqueous phase and the oil phase, thus, limiting the acidification of the external aqueous phase. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 02:10:40