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Titolo:
Effects of red wine, alcohol, and quercetin on coronary resistance and conductance arteries
Autore:
Rendig, SV; Symons, JD; Longhurst, JC; Amsterdam, EA;
Indirizzi:
Univ Calif Davis, Dept Internal Med, Div Cardiovasc Med, Davis, CA 95616 USA Univ Calif Davis Davis CA USA 95616 v Cardiovasc Med, Davis, CA 95616 USA Univ Calif Irvine, Dept Med, Irvine, CA 92717 USA Univ Calif Irvine Irvine CA USA 92717 ine, Dept Med, Irvine, CA 92717 USA
Titolo Testata:
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
fascicolo: 2, volume: 38, anno: 2001,
pagine: 219 - 227
SICI:
0160-2446(200108)38:2<219:EORWAA>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
ISCHEMIC-HEART-DISEASE; CARDIOVASCULAR MORTALITY; CONTRACTILE RESPONSES; MODERATE ALCOHOL; FRENCH PARADOX; RISK-FACTORS; CONSUMPTION; FLAVONOIDS; MEN; COUNTRIES;
Keywords:
acetylcholine; flavonoid; endothelium; microcirculation; vasodilation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Amsterdam, EA Univ Calif Davis, Ctr Ambulatory Care, 4860 Y St,Suite 2800,Sacramento, CA 95817 USA Univ Calif Davis 4860 Y St,Suite 2800 Sacramento CA USA 95817
Citazione:
S.V. Rendig et al., "Effects of red wine, alcohol, and quercetin on coronary resistance and conductance arteries", J CARDIO PH, 38(2), 2001, pp. 219-227

Abstract

Moderate consumption of alcoholic beverages is associated with a reduced risk of coronary heart disease (CHD). Some evidence suggests that red wine is particularly beneficial in this regard and may account in part for the French paradox, although the mechanism of this effect is unknown. We assessedthe effects of red wine, ethanol, and quercetin, a major flavonoid constituent of red wine, in coronary resistance vessels (80-150 mum, i.d.) and conductance vessels (300-525 mum, i.d.) of the rabbit. Vessel wall tension wasmeasured in isolated segments maintained in a wire-type myograph (37 degreesC) and preconstricted with 30 mM K+. At an alcohol concentration (14 mM) equivalent to moderate consumption, red wine evoked a small, transient constrictor effect in resistance and conductance vessels (9 +/- 4%, n = 5; 8 +/- 1%, n = 7, respectively; p < 0.05). Ethanol alone at this concentration was without effect. Quercetin (5.6, 8, and 30 <mu>M) significantly relaxed resistance (-32 +/- 4%, n = 10; -47 +/- 2%, n = 7; -82 +/- 6%, n = 8, respectively) and conductance (-20 +/- 3%, n = 8; -32 +/- 4%, n = 8; -72 +/- 7%, n = 8, respectively) coronary arteries. Vasorelaxation by quercetin was endothelium-independent and was significantly greater in resistance than in conductance vessels. These data suggest that red wine and ethanol do not evoke relaxation in small coronary arteries at concentrations associated with moderate consumption. Quercetin elicits marked coronary vasorelaxation that is endothelium-independent. However, the concentrations of quercetin necessary to achieve this action are not attained with moderate red wine consumption.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 16:11:56