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Titolo:
Bone reinnervation after fracture: A study in the rat
Autore:
Li, R; Ahmad, T; Spetea, M; Ahmed, M; Kreicbergs, A;
Indirizzi:
Karolinska Hosp, Dept Orthoped, Orthoped Lasb, Res Ctr M3 02, SE-17176 Stockholm, Sweden Karolinska Hosp Stockholm Sweden SE-17176 02, SE-17176 Stockholm, Sweden Innsbruck Univ, Div Pharmaceut Chem, Inst Pharm, A-6020 Innsbruck, AustriaInnsbruck Univ Innsbruck Austria A-6020 Pharm, A-6020 Innsbruck, Austria Aga Khan Univ Hosp, Dept Surg, Karachi, Pakistan Aga Khan Univ Hosp Karachi Pakistan Hosp, Dept Surg, Karachi, Pakistan
Titolo Testata:
JOURNAL OF BONE AND MINERAL RESEARCH
fascicolo: 8, volume: 16, anno: 2001,
pagine: 1505 - 1510
SICI:
0884-0431(200108)16:8<1505:BRAFAS>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
GENE-RELATED PEPTIDE; VASOACTIVE-INTESTINAL-PEPTIDE; SUBSTANCE-P; CALLUS FORMATION; NERVES; GROWTH; EXPRESSION; CELLS; IMMUNOREACTIVITY; PROLIFERATION;
Keywords:
fracture healing; nerve regeneration; fracture callus; growth-associated protein 43; protein gene product 9.5;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Li, R Karolinska Hosp, Dept Orthoped, Orthoped Lasb, Res Ctr M3 02, SE-17176 Stockholm, Sweden Karolinska Hosp Stockholm Sweden SE-17176 -17176 Stockholm, Sweden
Citazione:
R. Li et al., "Bone reinnervation after fracture: A study in the rat", J BONE MIN, 16(8), 2001, pp. 1505-1510

Abstract

Reinnervation after tibial fracture in the rat was studied by analyzing the occurrence of growth-associated protein 43 (GAP-43), a marker for regenerating nerve fibers, and protein gene product 9.5 (PGP-9.5), a marker for mature nerve fibers, by immunohistochemistry. At 3 days postfracture, GAP-43-immunoreactive nerve fibers were first observed in the fracture hematoma and periosteum. At 7 days postfracture, abundant sprouting of GAP-43-positivefibers was seen in the callus, hyperplastic periosteum, and edge of fibrocartilage. In the latter region, the nerve fibers were nonvascular, showing dense ramifications and terminal sprouting close to chondroid cells. At 14 days and 21 days postfracture, many GAP-43-positive fibers were still sprouting into the fibrocartilage and new woven bone. Fine varicose GAP-43-positive fibers also were present in the bone marrow. In contrast to GAP-43, PGP-9.5-positive nerve fibers were observed only occasionally at 3 days postfracture but gradually increased in number from day 14 to 21. Our study showsthat intense nerve regeneration occurs in early fracture healing partly unrelated to neovascularization. Considering that neuronal mediators have been shown to participate in local bone formation and resorption, the nerve regeneration observed may prove to be essential for delivery of neuronal mediators required for normal callus formation and/or neovascularization.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 01:04:54