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Titolo:
Maternal obesity and pregnancy outcome: a study of 287 213 pregnancies in London
Autore:
Sebire, NJ; Jolly, M; Harris, JP; Wadsworth, J; Joffe, M; Beard, RW; Regan, L; Robinson, S;
Indirizzi:
Univ London Imperial Coll Sci Technol & Med, St Marys Hosp,Sch Med, Dept Obstet & Gynaecol, Metab Med Unit, London W2, England Univ London Imperial Coll Sci Technol & Med London England W2 2, England Univ London Imperial Coll Sci Technol & Med, St Marys Hosp, Sch Med, Dept Publ Hlth Med, London W2, England Univ London Imperial Coll Sci Technol & Med London England W2 2, England Univ London Imperial Coll Sci Technol & Med, St Marys Hosp, Sch Med, Dept Metab Med, London W2, England Univ London Imperial Coll Sci Technol & Med London England W2 2, England
Titolo Testata:
INTERNATIONAL JOURNAL OF OBESITY
fascicolo: 8, volume: 25, anno: 2001,
pagine: 1175 - 1182
SICI:
0307-0565(200108)25:8<1175:MOAPOA>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
SOCIOECONOMIC-STATUS; WEIGHT-GAIN;
Keywords:
obesity; pregnancy; stillbirth;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Robinson, S Univ London Imperial Coll Sci Technol & Med, St Marys Hosp,SchMed, Dept Obstet & Gynaecol, Metab Med Unit, Praed St, London W2, England Univ London Imperial Coll Sci Technol & Med Praed St London England W2
Citazione:
N.J. Sebire et al., "Maternal obesity and pregnancy outcome: a study of 287 213 pregnancies in London", INT J OBES, 25(8), 2001, pp. 1175-1182

Abstract

OBJECTIVE: To examine the maternal and foetal risks of adverse pregnancy outcome in relation to maternal obesity, expressed as body mass index (BMI, kg/m(2)) in a large unselected geographical population. DESIGN: Retrospective analysis of data from a validated maternity databasesystem which includes all but one of the maternity units in the North WestThames Region. A comparison of pregnancy outcomes was made on the basis ofmaternal BMI at booking. SUBJECTS: A total of 287 213 completed singleton pregnancies were studied including 176 923 (61.6%) normal weight (BMI 20-24.9), 79 014 (27.5%) moderately obese (BMI 25 - 29.9) and 31 276 (10.9%) very obese (BMI greater thanor equal to 30) women. MEASUREMENTS: Ante-natal complications, intervention in labour, maternal morbidity and neonatal outcome were examined and data presented as raw frequencies and adjusted odds ratios with 99% confidence intervals following logistic regression analysis to account for confounding variables. RESULTS: Compared to women with normal BMI, the following outcomes were significantly more common in obese pregnant women (odds ratio (99% confidenceinterval) for BMI 25 - 30 and BMI greater than or equal to 30 respectively): gestational diabetes mellitus (1.68 (1.53 - 1.84), 3.6 (3.25 - 3.98)); proteinuric pre-eclampsia (1.44 (1.28 - 1.62), 2.14 (1.85 - 2.47)); induction of labour (2.14 (1.85 - 2.47), 1.70 (1.64 -1.76)); delivery by emergency caesarian section (1.30 (1.25 - 1.34), 1.83 (1.74 - 1.93)); postpartum haemorrhage (1.16 (1.12 - 1.21), 1.39 (1.32 - 1.46)); genital tract infection (1.24 (1.09 - 1.41), 1.30 (1.07 - 1.56)); urinary tract infection (1.17 (1.04 - 1.33), 1.39 (1.18 - 1.63)); wound infection (1.27 (1.09 - 1.48), 2.24 (1.91 - 2.64)); birthweight above the 90th centile (1.57 (1.50 - 1.64), 2.36(2.23 - 2.50)), and intrauterine death (1.10 (0.94 - 1.28), 1.40 (1.14 - 1.71)). However, delivery before 32 weeks' gestation (0.73 (0.65 - 0.82), 0.81 (0.69 - 0.95)) and breastfeeding at discharge (0.86 (0.84 - 0.88), 0.58 (0.56 - 0.60)) were significantly less likely in the overweight groups. In all cases, increasing maternal BMI was associated with increased magnitude of risk. CONCLUSION: Maternal obesity carries significant risks for the mother and foetus. The risk increases with the degree of obesity and persists after accounting for other confounding demographic factors. The basis of many of the complications is likely to be related to the altered metabolic state associated with morbid obesity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 21:38:04