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Titolo:
Inhibitory effects of mast cell-mediated allergic reactions by cell cultured Siberian Ginseng
Autore:
Jeong, HJ; Koo, HN; Myung, NI; Shin, MK; Kim, JW; Kim, DK; Kim, KS; Kim, HM; Lee, YM;
Indirizzi:
Wonkwang Univ, Coll Pharm, Dept Oriental Pharm, Iksan 570749, Chonbuk, South Korea Wonkwang Univ Iksan Chonbuk South Korea 570749 0749, Chonbuk, South Korea Wonkwang Univ, Ctr Oriental Med Sci, Iksan 570749, Chonbuk, South Korea Wonkwang Univ Iksan Chonbuk South Korea 570749 0749, Chonbuk, South Korea Wonkwang Univ, Dept Herbal, Coll Oriental Med, Iksan 570749, Chonbuk, South Korea Wonkwang Univ Iksan Chonbuk South Korea 570749 0749, Chonbuk, South Korea Microplants Co Ltd, Cell Culture Res Unit, Tukjin Gu, Chonju 561232, Chonbuk, South Korea Microplants Co Ltd Chonju Chonbuk South Korea 561232 Chonbuk, South Korea NIAID, Lab Allerg Div, NIH, Rockville, MD 20852 USA NIAID Rockville MD USA 20852 Lab Allerg Div, NIH, Rockville, MD 20852 USA Chonbuk Natl Univ, Coll Nat Sci, Div Biol Sci, Chonju 561756, Chonbuk, South Korea Chonbuk Natl Univ Chonju Chonbuk South Korea 561756 Chonbuk, South Korea
Titolo Testata:
IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY
fascicolo: 1, volume: 23, anno: 2001,
pagine: 107 - 117
SICI:
0892-3973(2001)23:1<107:IEOMCA>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACANTHOPANAX-SENTICOSUS; MESSENGER-RNA; HIGH-AFFINITY; IGE; ACTIVATION; RECEPTOR; RATS; ANAPHYLAXIS; SKIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Lee, YM Wonkwang Univ, Coll Pharm, Dept Oriental Pharm, Iksan 570749, Chonbuk, South Korea Wonkwang Univ Iksan Chonbuk South Korea 570749 onbuk, South Korea
Citazione:
H.J. Jeong et al., "Inhibitory effects of mast cell-mediated allergic reactions by cell cultured Siberian Ginseng", IMMUNOPH IM, 23(1), 2001, pp. 107-117

Abstract

The crude drug "Siberian Ginseng (SG)" has long been used in empirical Oriental medicine for the nonspecific enhancement of resistance in humans and animals. In this study, we investigated the effect of cell cultured SG by oral administration in mast cell-mediated allergic reactions. SG dose-dependently inhibited compound 48/80-induced systemic allergy with doses of 10(-2) to 1 g/kg 1 h before oral administration. Of special note, SG inhibited systemic allergy with the dose of I g/kg by 25%. SG (1 g/kg) also inhibited passive cutaneous allergic reaction by 51%. SG dose-dependently inhibited histamine release from rat peritoneal mast cells. When SG (0.01 mg/ml) was added, the secretion of tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 in antidinitrophenyl (DNP) IgE antibody-stimulated mast cells was inhibited 39.5% and 23.3%, respectively. In addition, SG inhibited anti-DNP IgE antibody-stimulated TNF-alpha protein expression in mast cells. Our studies provide evidence that SG may be beneficial in the treatment of various types of allergic diseases.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 07:44:23