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Titolo:
Cyclosporin A in patients affected by Chronic Idiopathic Urticaria: A therapeutic alternative
Autore:
Loria, MP; Dambra, PP; DOronzio, L; Nettis, E; Pannofino, A; Cavallo, E; Ferrannini, A; Tursi, A;
Indirizzi:
Univ Bari, Sez Allergol & Immunol Clin, Dipartimento Clin Med Immunol & Malattie Infett, Policlin, I-70124 Bari, Italy Univ Bari Bari Italy I-70124attie Infett, Policlin, I-70124 Bari, Italy
Titolo Testata:
IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY
fascicolo: 2, volume: 23, anno: 2001,
pagine: 205 - 213
SICI:
0892-3973(2001)23:2<205:CAIPAB>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
FC-EPSILON-RI; ANTI-IGE; B-CELLS; AUTOANTIBODIES; ANGIOEDEMA; LYMPHOCYTES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Loria, MP Univ Bari, Sez Allergol & Immunol Clin, Dipartimento Clin Med Immunol & Malattie Infett, Policlin, Piazza G Cesare, I-70124 Bari, Italy Univ Bari Piazza G Cesare Bari Italy I-70124 -70124 Bari, Italy
Citazione:
M.P. Loria et al., "Cyclosporin A in patients affected by Chronic Idiopathic Urticaria: A therapeutic alternative", IMMUNOPH IM, 23(2), 2001, pp. 205-213

Abstract

Chronic Idiopathic Urticaria (CIU) is a cutaneous disorder for which thereis no identifiable specific etiologic agent. Some recent evidences suggestthat CIU might be an autoimmune disease, We analyzed immunological features occurring in CIU and evaluated effectiveness and tolerance of CyclosporinA (CsA) treatment in patients unresponsive to antihistaminic treatment,Twenty patients with CIU were recruited after a selective diagnostic protocol and were divided into two groups, CsA was prescribed for group 1 and Prednisone for group 2 as control, for 8 weeks, Before and after the therapy we performed on all patients immunological studies,For all patients symptoms disappeared after a few days of therapy, Before therapy all patients showed activated B cells (CD19+CD23+ cells) and among B CD19+ cells, about 20% were CD5+ (cells that synthesize natural autoantibodies). After treatment with Prednisone in group 2. a significant reductionof CD4+ lymphocytes (p = 0.01) was observed,Our findings might support the CIU autoimmune pathogenetic hypothesis, Theclinical remission in the CsA-treated group confirmed the therapeutic effectiveness of this therapy in antihistaminic unresponsive CIU and, at dosageused, side effects were rare, mild and reversible. Thus, CsA might be a good therapeutic alternative in CIU patients unresponsive to conventional treatments.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 10:01:12