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Titolo:
Low-molecular-weight heparin for the prevention of obstetric complicationsin women with thrombophilias
Autore:
Kupferminc, MJ; Fait, G; Many, A; Lessing, JB; Yair, D; Bar-Am, A; Eldor, A;
Indirizzi:
Lis Matern Hosp, Dept Obstet & Gynecol, Tel Aviv, Israel Lis Matern Hosp Tel Aviv Israel Dept Obstet & Gynecol, Tel Aviv, Israel Tel Aviv Univ, Sackler Fac Med, Tel Aviv Sourasky Med Ctr, Dept Hematol, IL-69978 Tel Aviv, Israel Tel Aviv Univ Tel Aviv Israel IL-69978 ematol, IL-69978 Tel Aviv, Israel
Titolo Testata:
HYPERTENSION IN PREGNANCY
fascicolo: 1, volume: 20, anno: 2001,
pagine: 35 - 44
SICI:
1064-1955(2001)20:1<35:LHFTPO>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOW-DOSE ASPIRIN; FACTOR-V-LEIDEN; ANTIPHOSPHOLIPID SYNDROME; SEVERE PREECLAMPSIA; HIGH-RISK; PREGNANCIES; EXPERIENCE; MUTATION; THROMBOSIS; GROWTH;
Keywords:
pregnancy complications; preeclampsia; abruptio placentae; inherited thrombophilia; low-molecular-weight heparin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Kupferminc, MJ Lis Matern Hosp, Dept Obstet & Gynecol, Tel Aviv, Israel Lis Matern Hosp Tel Aviv Israel ynecol, Tel Aviv, Israel
Citazione:
M.J. Kupferminc et al., "Low-molecular-weight heparin for the prevention of obstetric complicationsin women with thrombophilias", HYPERTENS P, 20(1), 2001, pp. 35-44

Abstract

Objective. To evaluate the benefit of combined low-molecular-weight (LMW) heparin and aspirin for prophylaxis in women carriers of thrombophilia who had previously suffered from severe obstetric complications. Methods. The 33 studied women had an earlier pregnancy complicated by severe preeclampsia. abruptio placentae, intrauterine growth retardation, or intrauterine fetal death. All were subsequently diagnosed as carrying inherited thrombophilias. In their subsequent pregnancy, prophylactic therapy consisting of LMW heparin 40 mg/day (Enoxaparin, Rhone-Poulenc-Rorer, France) and aspirin was administered. Patients who were found to be homozygotes for the methylenetetrahydrofolate reductase mutation also received folic acid supplementation throughout their pregnancy. Results. Low-molecular-weight heparin was well tolerated and none of the women or the newborns developed any hemorrhagic complications. Only three (9.1%) of the women developed pregnancy complications. The mean gestational age and the mean birth weight at delivery in the previously complicated pregnancies were 32.1 +/- 5.0 weeks and 1175 +/-. 590 g, respectively, comparedto 37.6 +/- 2.3 weeks and 2719 +/- 526 g, respectively, in the treated pregnancies (p < 0.001). Conclusions. This uncontrolled trial suggests that patients with obstetriccomplications and an inherited thrombophilia may benefit from treatment with combined LMW heparin and aspirin in subsequent pregnancies. However, this needs to be verified by controlled trials before considering clinical application.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/09/20 alle ore 11:18:22