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Titolo:
Follicular adenoma with papillary architecture: a lesion mimicking papillary thyroid carcinoma
Autore:
Mai, KT; Landry, DC; Thomas, J; Burns, BF; Commons, AS; Yazdi, HM; Odell, PF;
Indirizzi:
Ottawa Civic Hosp, Dept Lab Med, Div Anat Pathol, Ottawa, ON K1Y 4E9, Canada Ottawa Civic Hosp Ottawa ON Canada K1Y 4E9 ol, Ottawa, ON K1Y 4E9, Canada Univ Ottawa, Dept Pathol & Lab Med, Ottawa, ON K1N 6N5, Canada Univ Ottawa Ottawa ON Canada K1N 6N5 Lab Med, Ottawa, ON K1N 6N5, Canada Ottawa Hosp, Dept Otorhinolaryngol, Ottawa, ON, Canada Ottawa Hosp OttawaON Canada , Dept Otorhinolaryngol, Ottawa, ON, Canada
Titolo Testata:
HISTOPATHOLOGY
fascicolo: 1, volume: 39, anno: 2001,
pagine: 25 - 32
SICI:
0309-0167(200107)39:1<25:FAWPAA>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
RET PROTOONCOGENE; ONCOGENE ACTIVATION; HIGH PREVALENCE; RET/PTC; EXPRESSION; TUMORS; CYTOKERATIN; BENIGN; REARRANGEMENTS; HBME-1;
Keywords:
papillary thyroid carcinoma; follicular adenoma; HBME; cytokeratin 19;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Mai, KT Ottawa Civic Hosp, Dept Lab Med, Div Anat Pathol, Civic Campus,1053 Carling Ave, Ottawa, ON K1Y 4E9, Canada Ottawa Civic Hosp Civic Campus,1053 Carling Ave Ottawa ON Canada K1Y 4E9
Citazione:
K.T. Mai et al., "Follicular adenoma with papillary architecture: a lesion mimicking papillary thyroid carcinoma", HISTOPATHOL, 39(1), 2001, pp. 25-32

Abstract

Aims: The purpose of this study was to investigate the significance of 'benign' encapsulated follicular thyroid nodules with papillary structures. Methods and results: Twenty-one cases of encapsulated neoplastic thyroid nodules with papillary structures and nuclear features not diagnostic of papillary thyroid carcinoma (PTC) were obtained, All cases were reviewed with particular attention to nuclear features (fine chromatin pattern, optical clearing, grooves and inclusions), Representative sections were submitted for measurement of the maximum diameter of,OO round or nearly round nuclei and for immunostaining for MIB1, CK19, HBME and Ret oncogene protein, Nine cases displayed scattered optically clear nuclei or nuclear grooves in less than 30% of total neoplastic cells. They were grouped in the category of thyroid nodules with limited nuclear features of papillary thyroid carcinoma (PTC), but not diagnostic of PTC. The other 12 cases had fine or coarse chromatin, but lacked other features of nuclei in PTC. The diameter of the nuclei ranged from 5.6 to 7.2 mum and were smaller than those of PTC (6.3-10.0 mum). Immunostaining revealed positive reactivity for MIB1 in the papillarystructures. Immunostaining for CK19 and HBME varied from negative or focally weak to diffusely moderate reactivity. Ret oncogene protein immunostaining showed focal and weak reactivity in one case and was negative in other cases of the study, Clinical follow-up from 6 months to 15 years revealed noevidence of metastasis. Conclusions: The papillary structures in the study cases are unlikely to represent degenerative changes due to their proliferative activity, In view of (i) the encapsulation and the uniformity of the constituent cells, (ii) the varying degrees of immunoreactivity for CK19 and HBME and negative immunoreactivity for Ret oncogene protein, and (iii) the absence or insufficiency of nuclear criteria for the diagnosis of PTC and the absence of lymph node metastasis in all study cases, we believe that these lesions represent the papillary variant of follicular adenoma. Recognition of this pathological entity is important to avoid an over-diagnosis of PTC.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 05:38:22