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Titolo:
Mild haemophilia A discovered in a previously multi-operated 73-year-old man: characterization of a new mutation
Autore:
Bauduer, F; Ducout, L; Bendriss, P; Falaises, B; Lavergne, JM;
Indirizzi:
Ctr Hosp Cote Basque, Serv Hematol, Dept Haematol, F-64100 Bayonne, FranceCtr Hosp Cote Basque Bayonne France F-64100 tol, F-64100 Bayonne, France Polyclin Aguilera, Dept Anaesthesiol, Biarritz, France Polyclin Aguilera Biarritz France , Dept Anaesthesiol, Biarritz, France Polyclin Aguilera, Dept Orthoped Surg, Biarritz, France Polyclin AguileraBiarritz France Dept Orthoped Surg, Biarritz, France Hop Bicetre, INSERM, U143, Le Kremlin Bicetre, France Hop Bicetre Le Kremlin Bicetre France U143, Le Kremlin Bicetre, France
Titolo Testata:
HAEMOPHILIA
fascicolo: 4, volume: 7, anno: 2001,
pagine: 419 - 421
SICI:
1351-8216(200107)7:4<419:MHADIA>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEMOPHILIA-A; TOTAL KNEE;
Keywords:
elderly; haemophilia A; mutation; recombinant factor VII; total knee arthroplasty;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
9
Recensione:
Indirizzi per estratti:
Indirizzo: Bauduer, F Ctr Hosp Cote Basque, Serv Hematol, Dept Haematol, F-64100 Bayonne, France Ctr Hosp Cote Basque Bayonne France F-64100 0 Bayonne, France
Citazione:
F. Bauduer et al., "Mild haemophilia A discovered in a previously multi-operated 73-year-old man: characterization of a new mutation", HAEMOPHILIA, 7(4), 2001, pp. 419-421

Abstract

A mild haemophilia A (factor VIII [FVIII] 10%) was discovered in a 73-year-old man during the preoperative haemostasis tests before a total knee arthroplasty for treatment of degenerative senile arthropathy. No history of previous abnormal bleeding was noted in spite of several previous challengingsurgical procedures. Acquired haemophilia was ruled out and no other casesof haemophilia were found in the family. The surgery was successfully performed under recombinant FVIII aimed at achieving an FVIII level above 60%. This therapy induced the transient appearance of low-titre FVIII antibodies. A still unpublished mutation within the exon 3 (Gly73Ala) was found with molecular studies. This case report underlines the importance of haemostasis tests before high-risk bleeding surgical procedures even in elderly patients without a past history of haemorrhagic tendency.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/04/20 alle ore 09:09:20