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Titolo:
Identification and characterization of DAlk: a novel Drosophila melanogaster RTK which drives ERK activation in vivo
Autore:
Loren, CE; Scully, A; Grabbe, C; Edeen, PT; Thomas, J; McKeown, M; Hunter, T; Palmer, RH;
Indirizzi:
Umea Univ, Umea Ctr Mol Pathogenesis, S-90187 Umea, Sweden Umea Univ Umea Sweden S-90187 Ctr Mol Pathogenesis, S-90187 Umea, Sweden Salk Inst Biol Studies, Mol Biol & Virol Lab, La Jolla, CA 92037 USA Salk Inst Biol Studies La Jolla CA USA 92037 Lab, La Jolla, CA 92037 USA
Titolo Testata:
GENES TO CELLS
fascicolo: 6, volume: 6, anno: 2001,
pagine: 531 - 544
SICI:
1356-9597(200106)6:6<531:IACODA>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECEPTOR TYROSINE KINASE; GROWTH-FACTOR RECEPTOR; NON-HODGKINS-LYMPHOMA; LARGE-CELL LYMPHOMA; INSULIN-RECEPTOR; NERVOUS-SYSTEM; GENOME PROJECT; FGF-RECEPTOR; ATIC-ALK; GENE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
57
Recensione:
Indirizzi per estratti:
Indirizzo: Palmer, RH Umea Univ, Umea Ctr Mol Pathogenesis, Bldg 6L, S-90187 Umea, Sweden Umea Univ Bldg 6L Umea Sweden S-90187 6L, S-90187 Umea, Sweden
Citazione:
C.E. Loren et al., "Identification and characterization of DAlk: a novel Drosophila melanogaster RTK which drives ERK activation in vivo", GENES CELLS, 6(6), 2001, pp. 531-544

Abstract

Background: The mammalian receptor protein tyrosine kinase (RTK), Anaplastic Lymphoma Kinase (ALK), was first described as the product of the t(2;5) chromosomal translocation found in non-Hodgkin's lymphoma. While the mechanism of ALK activation in non-Hodgkin's lymphoma has been examined, to date,no in vivo role for this orphan insulin receptor family RTK has been described. Results: We describe here a novel Drosophila melanogaster RTK, DAlk, whichwe have mapped to band 53 on the right arm of the second chromosome. Full-length DALk cDNA encodes a phosphoprotein of 200 kDa, which shares homologynot only with mammalian ALK but also with the orphan RTK LTK. Analysis of both mammalian and Drosophila ALK reveals that the ALK family of RTKs contains a newly identified IMAM domain within their extracellular domains. Likeits mammalian counterpart, DALk appears to be expressed in the developing CNS by in situ analysis. However, in addition to expression of DAlk in the Drosophila brain, careful analysis reveals an additional early role for DAlk in the developing visceral mesoderm where its expression is coincident with activated ERK. Conclusion: In this paper we describe a Drosophila melanogaster Alk RTK which is expressed in the developing embryonic mesoderm and CNS. Our data provide evidence for the existence of a DAlk RTK pathway in Drosophila. We show that ERK participates in this pathway, and that it is activated by DAlk in vivo. Expression patterns of dALK, together with activated ERK, suggest that DAlk fulfils the criteria of the missing RTK pathway, leading to ERK activation in the developing visceral mesoderm.

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Documento generato il 31/03/20 alle ore 10:07:32