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Titolo:
Gemfibrozil improves insulin sensitivity and flow-mediated vasodilatation in type 2 diabetic patients
Autore:
Avogaro, A; Miola, M; Favaro, A; Gottardo, L; Pacini, G; Manzato, E; Zambon, S; Sacerdoti, D; de Kreutzenberg, S; Piliego, T; Tiengo, A; Del Prato, S;
Indirizzi:
Univ Padua, Sch Med, Dept Clin & Expt Med, I-35100 Padua, Italy Univ Padua Padua Italy I-35100 ept Clin & Expt Med, I-35100 Padua, Italy CNR, LADSEB, Padua, Italy CNR Padua ItalyCNR, LADSEB, Padua, Italy Parke Davis Italia, Milan, Italy Parke Davis Italia Milan ItalyParke Davis Italia, Milan, Italy Univ Padua, Dept Internal Med, I-35100 Padua, Italy Univ Padua Padua Italy I-35100 , Dept Internal Med, I-35100 Padua, Italy
Titolo Testata:
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
fascicolo: 7, volume: 31, anno: 2001,
pagine: 603 - 609
SICI:
0014-2972(200107)31:7<603:GIISAF>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
LIPOPROTEIN PARTICLE-SIZE; HIGH-FAT MEAL; ENDOTHELIAL FUNCTION; NITRIC-OXIDE; VASCULAR REACTIVITY; GLUCOSE-TOLERANCE; RISK-FACTORS; MELLITUS; HYPERTRIGLYCERIDEMIA; RELAXATION;
Keywords:
diabetes mellitus; endothelium; insulin action; lipoproteins; triglycerides;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Avogaro, A Univ Padua, Sch Med, Dept Clin & Expt Med, Via Giustiniani 2, I-35100 Padua, Italy Univ Padua Via Giustiniani 2 Padua Italy I-35100 Padua, Italy
Citazione:
A. Avogaro et al., "Gemfibrozil improves insulin sensitivity and flow-mediated vasodilatation in type 2 diabetic patients", EUR J CL IN, 31(7), 2001, pp. 603-609

Abstract

Background Endothelial dysfunction is an early feature of atherosclerosis. The relationship between insulin action and hypertriglyceridaemia on endothelial function is still debated. Materials and Methods This study was designed to determine the effect of a3 month treatment with Gemfibrozil (GF) on flow-mediated vasodilatation and insulin sensitivity. Ten type 2 diabetic patients were randomised in crossover, double blind fashion, either to GF, 600 mg b.i.d. or placebo, for 12weeks. Lipid profile, low-density lipoprotein (LDL) distribution and flotation properties, insulin action and flow-mediated vasodilatation (FMD) by brachial artery ultrasound, were assessed. Results GF decreased serum triglyceride (TG) concentration with an absolute difference of 1.79 +/- 1.28 mmol L-1 (P < 0.0016) between active treatment and placebo, and significantly increased serum high-density lipoprotein (HIDL) cholesterol (P = 0.0233). No differences were observed in total, intermediate-density lipoproteins (IDL), LDL cholesterol concentration and LDL peak buoyancy between treatments. GF also improved SI, an index of insulin action (P = 0.005). The FMD was 7 +/- 3% in the baseline condition, 7 +/- 2% during placebo and 14 +/- 3% after GF (P < 0.006). Conclusions GF treatment improves both insulin action and flow-mediated vasodilatation in type 2 diabetic patients. The reduction of TG concentrationallows the simultaneous correction of two important components of the metabolic syndrome.

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Documento generato il 23/01/20 alle ore 12:16:47