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Titolo:
Variation at the cholesteryl ester transfer protein gene in relation to plasma high density lipoproteins cholesterol levels and carotid intima-media thickness
Autore:
Kakko, S; Tamminen, M; Paivansalo, M; Kauma, H; Rantala, AO; Lilja, M; Reunanen, A; Kesaniemi, YA; Savolainen, MJ;
Indirizzi:
Univ Oulu, Dept Internal Med, FIN-90220 Oulu, Finland Univ Oulu Oulu Finland FIN-90220 t Internal Med, FIN-90220 Oulu, Finland Univ Oulu, Bioctr, Oulu, Finland Univ Oulu Oulu FinlandUniv Oulu, Bioctr, Oulu, Finland Univ Oulu, Dept Diagnost Radiol, Oulu, Finland Univ Oulu Oulu FinlandUniv Oulu, Dept Diagnost Radiol, Oulu, Finland Natl Publ Hlth Inst, Helsinki, Finland Natl Publ Hlth Inst Helsinki Finland Publ Hlth Inst, Helsinki, Finland
Titolo Testata:
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
fascicolo: 7, volume: 31, anno: 2001,
pagine: 593 - 602
SICI:
0014-2972(200107)31:7<593:VATCET>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY HEART-DISEASE; CETP GENE; HDL-CHOLESTEROL; TRANSGENIC MICE; POLYMORPHISM; ASSOCIATION; ATHEROSCLEROSIS; ALCOHOL; RISK; MUTATION;
Keywords:
atherosclerosis; cholesteryl ester transfer protein; genetic polymorphism; high density lipoproteins; intima-media thickness;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Kakko, S Univ Oulu, Dept Internal Med, Kajaanintie 50, FIN-90220 Oulu, Finland Univ Oulu Kajaanintie 50 Oulu Finland FIN-90220 20 Oulu, Finland
Citazione:
S. Kakko et al., "Variation at the cholesteryl ester transfer protein gene in relation to plasma high density lipoproteins cholesterol levels and carotid intima-media thickness", EUR J CL IN, 31(7), 2001, pp. 593-602

Abstract

Background Cholesteryl ester transfer protein (CETP) plays a major role inlipoprotein metabolism. We have screened the CETP gene for mutations and polymorphisms regulating high density lipoproteins cholesterol (HDLC) levelsand the development of atherosclerosis, and found some polymorphisms (I405V and R451Q) to have minor effects. Design The purpose of this study was to investigate the combined effect ofthe several polymorphisms of the CETP gene so far found on HDL-C levels and carotid intima-media thickness (IMT), and, in addition, to study whether the recently found functional polymorphism in the promoter region of the CETP gene (C to A, - 629 relative to the first transcribed nucleotide) explains the previous associations due to linkage disequilibrium. The genotypes were determined in a population sample of 481 men and women. Results There were no significant differences in plasma CETP activity or carotid IMT between the genotypes of the promoter polymorphism. The women with the CC genotype of the promoter polymorphism had the lowest HDLC levels (P < 0001), but no such difference was seen in men. Detected polymorphisms of the CETP gene explained about 8% of the variation in HDLC in women and about 7 and 10% of the variation in carotid IMT in women and men, respectively. The associations of the promoter, I405V and R451Q-A373P polymorphisms with HDL-C and carotid IMT seemed to be independent of each other. The associations with IMT were independent of total HDL-C levels, suggesting that HDL subfractions may have more effect on IMT. Conclusion The CETP gene locus was found to be polymorphic and its polymorphisms explained a reasonable proportion of the variation in the degree of carotid atherosclerosis.

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Documento generato il 13/07/20 alle ore 10:15:28