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Titolo:
Effect of G-CSF on ethanol-induced hemorrhagic gastritis model in diabetesmellitus-induced rats
Autore:
Canturk, Z; Canturk, NZ; Cetinarslan, B; Senturk, O; Ercin, C; Yenise, C;
Indirizzi:
Kocaeli Univ, Sch Med, Dept Pathol, Kocaeli, Turkey Kocaeli Univ KocaeliTurkey Univ, Sch Med, Dept Pathol, Kocaeli, Turkey Kocaeli Univ, Sch Med, Dept Gen Surg, Kocaeli, Turkey Kocaeli Univ Kocaeli Turkey iv, Sch Med, Dept Gen Surg, Kocaeli, Turkey Kocaeli Univ, Sch Med, Dept Internal Med, Kocaeli, Turkey Kocaeli Univ Kocaeli Turkey Sch Med, Dept Internal Med, Kocaeli, Turkey Adnan Menderes Univ, Sch Med, Dept Biochem, Aydin, Turkey Adnan Menderes Univ Aydin Turkey , Sch Med, Dept Biochem, Aydin, Turkey
Titolo Testata:
ENDOCRINE RESEARCH
fascicolo: 1-2, volume: 27, anno: 2001,
pagine: 191 - 201
SICI:
0743-5800(2001)27:1-2<191:EOGOEH>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
COLONY-STIMULATING FACTOR; NECROSIS-FACTOR-ALPHA; NEUTROPHIL FUNCTIONS; RHG-CSF; GRANULOCYTE; ULCERATION; CHILDREN; STREPTOZOTOCIN; DISEASE; LESIONS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Canturk, Z Kocaeli Univ Tip Fakultesi, Ic Hastahklari Anabilim Dali Derince, TR-41900Kocaeli, Turkey Kocaeli Univ Tip Fakultesi Ic Hastahklari Anabilim Dali Derince Kocaeli Turkey TR-41900
Citazione:
Z. Canturk et al., "Effect of G-CSF on ethanol-induced hemorrhagic gastritis model in diabetesmellitus-induced rats", ENDOCRINE R, 27(1-2), 2001, pp. 191-201

Abstract

Diabetes mellitus can affect every organ system, including large and smallvessels, eyes, nerves, kidneys and gastrointestinal system. Acid peptic disease is an inflammatory condition involving the upper gastrointestinal tract. The elevated serum glucose levels of diabetics affect traditional host defenses such as neutrophil counts and functions. We aimed to investigate changes of gastric mucosa and the role of impaired neutrophil functions in adiabetes-induced experimental model and whether G-CSF, which modulates neutrophil counts and function, has protective effects against gastric mucosalinjury in diabetic rats. Fifty rats were divided into three groups. Diabetes mellitus was induced by a single dose of streptozotocin in 40 of 50 rats. Controls had a sham injection. The gastric mucosal lesions were produced by intragastric administration of 1 ml of 95% ethanol in all three groups. Granulocyte colony-stimulating factor (G-CSF) was subcutaneously injected to twenty of diabetes-induced rats. Stomach histology and tissue malondialdehyde and glutathione levels were determined. White blood cell count, neutrophil counts and functionswere determined. Peripheral blood cell counts, neutrophil phagocytosis index were decreasedbut neutrophil adhesivity index was not different in diabetes-induced groups. G-CSF administration improved neutrophil counts and function. Macroscopic and microscopic gastric mucosal injury were significantly greater in control and only diabetes group compared with G-CSF pretreated group (p < 0.05). The tissue malondialdehyde and glutathione levels were: significantly decreased in G-CSF-administrated diabetic group compared to untreated diabetics (p < 0.001). Finally, G-CSF has been shown to cause neutrophilia and improve neutrophilphagocytosis in diabetic. G-CSF may be cytoprotective for gastric mucosa in diabetes mellitus-induced rats.

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Documento generato il 05/04/20 alle ore 07:01:51