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Titolo:
Clinical and economic factors in the treatment of behavioural and psychological symptoms of dementia
Autore:
Hemels, MEH; Lanctot, KL; Iskedjian, M; Einarson, TR;
Indirizzi:
Univ Toronto, Fac Pharm, Toronto, ON M5S 2S2, Canada Univ Toronto TorontoON Canada M5S 2S2 Pharm, Toronto, ON M5S 2S2, Canada Univ Toronto, Fac Med, Dept Hlth Adm, Toronto, ON M5S 2S2, Canada Univ Toronto Toronto ON Canada M5S 2S2 h Adm, Toronto, ON M5S 2S2, Canada Univ Toronto, Grad Fac Pharmaceut Sci, Toronto, ON, Canada Univ Toronto Toronto ON Canada d Fac Pharmaceut Sci, Toronto, ON, Canada Univ Toronto, Sunnybrook & Womens Hlth Sci Ctr, Hlth Outcomes & Pharacoecon Res Ctr, Toronto, ON, Canada Univ Toronto Toronto ON Canada Pharacoecon Res Ctr, Toronto, ON, Canada Pharmideas Res & Consulting Inc, Hamilton, ON, Canada Pharmideas Res & Consulting Inc Hamilton ON Canada Hamilton, ON, Canada
Titolo Testata:
DRUGS & AGING
fascicolo: 7, volume: 18, anno: 2001,
pagine: 527 - 550
SICI:
1170-229X(2001)18:7<527:CAEFIT>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
NURSING-HOME PATIENTS; COST-EFFECTIVENESS ANALYSIS; PLACEBO-CONTROLLED TRIAL; QUALITY-OF-LIFE; ALZHEIMERS-DISEASE; ELDERLY PATIENTS; DOUBLE-BLIND; PSYCHIATRIC-SYMPTOMS; COMPREHENSIVE ASSESSMENT; DISRUPTIVE BEHAVIORS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
179
Recensione:
Indirizzi per estratti:
Indirizzo: Einarson, TR Univ Toronto, Fac Pharm, 19 Russell St, Toronto, ON M5S 2S2, Canada Univ Toronto 19 Russell St Toronto ON Canada M5S 2S2 , Canada
Citazione:
M.E.H. Hemels et al., "Clinical and economic factors in the treatment of behavioural and psychological symptoms of dementia", DRUG AGING, 18(7), 2001, pp. 527-550

Abstract

The prevalence of behavioural and psychological symptoms of dementia (BPSD) exceeds 50% They cause distress to patients and caregivers, increase . resource utilisation of various kinds, and form a high risk for accelerated psychiatric care through institutionalisation. Although evidence fur current pharmacological treatment is not strong and the construct of BPSD is still not very clear, future aspects of treatment of BPSD may be positive. If we look at overall success rates of the antipsychotics, the traditional antipsychotics have the highest combined success rate of 63.1%, whereas the novel antipsychotics have an overall success rateof 56.1%. Haloperidol is the drug with the highest success rate of 65.4%, although this drug is associated with parkinsonian adverse drug reactions. Newer antipsychotics show promise in treating BPSD, but more convincing evidence (e.g. from randomised clinical trials) is required. We provide an overview of the clinical, epidemiological and economic aspects of BPSD and a review of the available literature on their pharmacological treatment. Although only 1 pharmacoeconomic study has been conducted on BPSD, it seems likely that these manifestations drastically increase the: burden of dementia.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/21 alle ore 03:41:08