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Titolo:
Molecular properties of propranolol hydrochloride prepared as drug-resin complexes
Autore:
Akkaramongkolporn, P; Terada, K; Yonemochi, E;
Indirizzi:
Silpakorn Univ, Fac Pharm, Dept Pharmaceut Technol, Nakorn Pathom, Thailand Silpakorn Univ Nakorn Pathom Thailand Technol, Nakorn Pathom, Thailand Toho Univ, Sch Pharmaceut Sci, Dept Pharmaceut, Tokyo, Japan Toho Univ Tokyo Japan Sch Pharmaceut Sci, Dept Pharmaceut, Tokyo, Japan
Titolo Testata:
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
fascicolo: 4, volume: 27, anno: 2001,
pagine: 359 - 364
SICI:
0363-9045(2001)27:4<359:MPOPHP>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
ION-EXCHANGE RESIN; BETA-CYCLODEXTRIN; DELIVERY; RELEASE;
Keywords:
differential scanning calorimetry; infrared spectroscopy; ion exchange; propranolol hydrochloride; release behavior; X-ray diffraction;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
16
Recensione:
Indirizzi per estratti:
Indirizzo: Akkaramongkolporn, P Silpakorn Univ, Fac Pharm, Dept Pharmaceut Technol, Nakorn Pathom, Thailand Silpakorn Univ Nakorn Pathom Thailand om, Thailand
Citazione:
P. Akkaramongkolporn et al., "Molecular properties of propranolol hydrochloride prepared as drug-resin complexes", DRUG DEV IN, 27(4), 2001, pp. 359-364

Abstract

Drug-resin complexes, as well as physical dispersion , containing varying contents of propranolol were prepared. The molecular properties of samples were investigated by differential scanning calorimetry (DSC), X-ray powder diffraction (XRPD), and infrared (IR) spectroscopy. In addition, the USP paddle method was used to determine the release behavior of drug from variousformulations prepared from the samples. The data from DSC and XRPD indicated that the molecular state of drug in the complexes was amorphous, wheras that in the physical dispersion exhibited the crystalline state of pure drug. These results suggested that the molecule of drug prepared as drug-resincomplexes was monomolecularly dispersed in the resin bead. The IR study provided evidence that demonstrated the interaction between the drug and resin in the complexes. The release behavior of drug from the complexes was governed by the cross-linkage structure and equilibrium treatment of drug exchange of resin.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 14:48:02