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Titolo:
Optimization of an exogenous metabolic activation system for FETAX. I. Post-isolation rat liver microsome mixtures
Autore:
Fort, DJ; Rogers, RL; Stover, EL; Finch, RA;
Indirizzi:
Ft Environm Labs Inc, Stillwater, OK USA Ft Environm Labs Inc Stillwater OK USA ronm Labs Inc, Stillwater, OK USA Stover Grp, Stillwater, OK USA Stover Grp Stillwater OK USAStover Grp, Stillwater, OK USA USA, Ctr Environm Hlth Res, Frederick, MD USA USA Frederick MD USAUSA, Ctr Environm Hlth Res, Frederick, MD USA Oklahoma State Univ, Dept Zool, Stillwater, OK 74078 USA Oklahoma State Univ Stillwater OK USA 74078 ool, Stillwater, OK 74078 USA
Titolo Testata:
DRUG AND CHEMICAL TOXICOLOGY
fascicolo: 2, volume: 24, anno: 2001,
pagine: 103 - 115
SICI:
0148-0545(2001)24:2<103:OOAEMA>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
EMBRYO TERATOGENESIS ASSAY; DEVELOPMENTAL TOXICITY; XENOPUS FETAX; VALIDATION; COUMARIN;
Keywords:
FETAX; metabolic activation system; developmental toxicity; Xenopus;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Fort, DJ 1414 S Sangre Rd, Stillwater, OK 74074 USA 1414 S Sangre Rd Stillwater OK USA 74074 tillwater, OK 74074 USA
Citazione:
D.J. Fort et al., "Optimization of an exogenous metabolic activation system for FETAX. I. Post-isolation rat liver microsome mixtures", DRUG CHEM T, 24(2), 2001, pp. 103-115

Abstract

The developmental toxicity of cyclophosphamide, coumarin, 2-acetyl-aminofluorine (2-AAF), and trichloroethylene (TCE) was assessed with Frog Embryo Teratogenesis Assay: Xenopus (FETAX). Late Xenopus laevis blastulae were exposed to each test material for 96-h in two separate static-renewal tests with and without the presence of five differently induced exogenous metabolicactivation systems (MAS). The MAS consisted of Aroclor 1254- (Aroclor 1254MAS). isoniazid- (INH MAS), phenobarbital- (PB MAS), or beta -naphthoflavone- (beta -NF MAS), or a post-isolation mixture (mixed MAS) of INH-. PB-, and beta -NF-induced rat liver microsomes. Addition of the Aroclor 1254 MAS bioactivated cyclophosphamide, coumarin, 2-AAF, but not TCE. Addition of the PB MAS bioactivated cyclophosphamide, weakly bioactivated coumarin and 2-AAF, but had no effect on TCE developmental toxicity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/04/20 alle ore 09:07:24