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Titolo:
Treatment of liver metastases from colorectal cancer: what is the best approach today?
Autore:
Biasco, G; Gallerani, E;
Indirizzi:
Univ Bologna, Osped Orsola Malpighi, Inst Hematol & Med Oncol L&A Seragnoli, I-40138 Bologna, Italy Univ Bologna Bologna Italy I-40138 L&A Seragnoli, I-40138 Bologna, Italy
Titolo Testata:
DIGESTIVE AND LIVER DISEASE
fascicolo: 5, volume: 33, anno: 2001,
pagine: 438 - 444
SICI:
1590-8658(200106/07)33:5<438:TOLMFC>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEPATIC ARTERIAL INFUSION; MULTICENTER RANDOMIZED TRIAL; LYMPH-NODE INVOLVEMENT; FIRST-LINE TREATMENT; LONG-TERM SURVIVAL; FLUOROURACIL FAILURE; SURGICAL RESECTION; FOLINIC ACID; OXALIPLATIN; CARCINOMA;
Keywords:
colorectal cancer; liver metastases; local chemotherapy; systemic chemotherapy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Biasco, G Univ Bologna, Osped Orsola Malpighi, Inst Hematol & Med Oncol L&A Seragnoli, Via Massarenti 9, I-40138 Bologna, Italy Univ Bologna Via Massarenti 9 Bologna Italy I-40138 ogna, Italy
Citazione:
G. Biasco e E. Gallerani, "Treatment of liver metastases from colorectal cancer: what is the best approach today?", DIG LIVER D, 33(5), 2001, pp. 438-444

Abstract

Liver is the common site for metastases from colorectal cancer The 5-year overall survival rate of patients following radical operations is 25%. Surgery can be carried out in only 10-15% of the patients, yet it remains the potential curative treatment for resectable lesions. For the unresectable cancers, only chemotherapy is recommended. New drugs such as Irinotecan prolongs the overall survival of patients affected by advanced disease. In patients with unresectable metastases at diagnosis, pre-surgical treatment with Oxaliplatin leads to reduction of the lesions, allowing resection in 16% ofcases. Chemotherapy may be delivered directly into the liver via the hepatic artery. No, clinical trials, to date, have shown convincing survival results in patients treated with this procedure. Combined hepatic artery and systemic treatment may provide a new strategy as adjuvant therapy for patients undergoing resections.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/02/20 alle ore 06:07:21