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Titolo:
Serological markers for coeliac disease: is it time to change?
Autore:
Bardella, MT; Trovato, C; Cesana, BM; Pagliari, C; Gebbia, C; Peracchi, M;
Indirizzi:
Univ Milan, IRCCS Osped Maggiore, Dept Gastroenterol, I-20122 Milan, ItalyUniv Milan Milan Italy I-20122 Dept Gastroenterol, I-20122 Milan, Italy Univ Milan, IRCCS Osped Maggiore, Epidemiol Unit, I-20122 Milan, Italy Univ Milan Milan Italy I-20122 ore, Epidemiol Unit, I-20122 Milan, Italy
Titolo Testata:
DIGESTIVE AND LIVER DISEASE
fascicolo: 5, volume: 33, anno: 2001,
pagine: 426 - 431
SICI:
1590-8658(200106/07)33:5<426:SMFCDI>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
TISSUE TRANSGLUTAMINASE ELISA; ADULT CELIAC-DISEASE; ANTIGLIADIN ANTIBODIES; UMBILICAL-CORD; FOLLOW-UP; IGA-CLASS; AUTOANTIBODIES; TESTS;
Keywords:
coeliac disease; anti-tissue transglutaminase;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Bardella, MT Univ Milan, IRCCS Osped Maggiore, Dept Gastroenterol, Granelli III Piano,Via F Sforza 35, I-20122 Milan, Italy Univ Milan Granelli III Piano,Via F Sforza 35 Milan Italy I-20122
Citazione:
M.T. Bardella et al., "Serological markers for coeliac disease: is it time to change?", DIG LIVER D, 33(5), 2001, pp. 426-431

Abstract

Background. Anti-gliadin and anti-endomysium antibodies are useful markersin the screening and follow-up of coeliac disease. The recent finding thattissue transglutaminase is the main auto-antigen of anti-endomysium has led to the discovery of anti-tissue transglutaminase antibodiesAim. To compare, in a prospective study, the diagnostic accuracy of anti-tissue transglutaminase, anti-gliadin and anti-endomysium antibodies in a large series of adult patients. Methods. The study involved 80 consecutive subjects undergoing upper gastrointestinal tract endoscopy for suspected coeliac disease (subsequently confirmed in 40 cases), 195 coeliac patients an a gluten-free diet, and 70 patients with different gastrointestinal disorders and normal duodenal histology. Anti-gliadin, anti-endomysium and anti-tissue transglutaminase antibodies levels were measured using commercial kits. Results. The diagnostic sensitivity and specificity of anti-gliadin, anti-endomysium and anti-tissue transglutaminase antibodies were, respectively, 95% and 89.1%, 100% and 97.3%, and 100% and 98.2%: the agreement between the markers was substantial or, almost perfect. In terms of follow-up, the positivity of the markers varied according to the strict adherence to, and duration of the gluten-free diet; the agreement between anti-endomysium and anti-tissue transglutaminase antibodies was almost perfect. Conclusions. Anti-endomysium and anti-tissue transglutaminase antibodies are both highly efficient for routine laboratory screening: the choice of one or the other will depend on the available facilities. However, neither can replace intestinal biopsy for general population screening because, in this case, their respective positive predictive values are only 15.7% and 21.8%. During follow-up, and-gliadin retain their value as an early predictor,of gluten ingestion.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 21:41:13