Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Effect of cisapride on gastric sensitivity to distension, gastric compliance and duodeno-gastric reflexes in healthy humans
Autore:
Manes, G; Dominguez-Munoz, JE; Leodolter, A; Malfertheiner, P;
Indirizzi:
Univ Magdeburg, Klin Gastroenterol, Dept Gastroenterol Hepatol & Infect Dis, D-39120 Magdeburg, Germany Univ Magdeburg Magdeburg Germany D-39120 Dis, D-39120 Magdeburg, Germany Cardarelli Hosp, Dept Gastroenterol, Naples, Italy Cardarelli Hosp Naples Italy li Hosp, Dept Gastroenterol, Naples, Italy Univ Santiago de Compostela, Dept Gastroenterol, Santiago De Compostela, Spain Univ Santiago de Compostela Santiago De Compostela Spain postela, Spain
Titolo Testata:
DIGESTIVE AND LIVER DISEASE
fascicolo: 5, volume: 33, anno: 2001,
pagine: 407 - 413
SICI:
1590-8658(200106/07)33:5<407:EOCOGS>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
FUNCTIONAL DYSPEPSIA; GASTROINTESTINAL MOTILITY; MOTOR-ACTIVITY; TONE; PERCEPTION; RESPONSES; MEAL; INHIBITION; STOMACH; DEPENDS;
Keywords:
barostat; cisapride; dyspepsia; gastric distension; gastric relaxation; gastric sensitivity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Malfertheiner, P Univ Magdeburg, Klin Gastroenterol, Dept Gastroenterol Hepatol & Infect Dis, Leipziger Str 44, D-39120 Magdeburg, Germany Univ Magdeburg Leipziger Str 44 Magdeburg Germany D-39120
Citazione:
G. Manes et al., "Effect of cisapride on gastric sensitivity to distension, gastric compliance and duodeno-gastric reflexes in healthy humans", DIG LIVER D, 33(5), 2001, pp. 407-413

Abstract

Background and aims. Visceral hypersensitivity and impaired gastric relaxation after the ingestion of a meal are frequent features in patients with functional dyspepsia. Cisapride improves dyspeptic symptoms. The study aims to evaluate whether cisapride influences gastric sensitivity to distension as well as gastric compliance and duodenogastric reflexes. Patients and methods. Eight healthy males were studied on two different days, each after 7 days' treatment either with placebo or cisapride 10 mg qidin randomized order. A spherical bag connected to a barostat was placed inthe gastric fundus and an B-lumen manometric catheter was positioned with 4 side holes in antrum and 4 in duodenum. During a phase II of the migrating motor complex, the intragastric bag was inflated at a constant pressure Imm Hg above the intra-abdominal pressure and the gastric volume was measured during intraduodenal infusion of lipids and citric acid at different rates. Once the stomach returned to the basal volume, the bag was distended according to two different protocols until subjects reported discomfort. Antroduodenal motility was measured throughout the study. Results. Intraduodenal infusion of lipids and citric acid caused relaxation of gastric fundus. Relaxation was similar for lipids and acid (203 +/- 30vs 199 +/- 43 ml), and was not influenced by cisapride and infusion rate. Cisapride did not influence gastric sensitivity to distension (10 +/-1.5 vs9.7 +/-1.3 mm Hg) and gastric compliance (52.7 +/-1.2 vs 49.8 +/-1.8 ml/mmHg). The antral motor index significantly decreased following infusion of acid and lipids with placebo but not with cisapride. Conclusions. Cisapride inhibits the physiological duodenoantral reflexes but does not influence either the mechanical properties of the gastric fundus nor the gastric sensitivity to distension.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 23:47:04