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Titolo:
Insulin secretion and glucose kinetics during exercise with and without pharmacological alpha(1)- and alpha(2)-receptor blockade
Autore:
Aarnio, P; Lauritsen, T; Dela, F;
Indirizzi:
Univ Copenhagen, Panum Inst, Dept Med Physiol, DK-2200 Copenhagen N, Denmark Univ Copenhagen Copenhagen Denmark N siol, DK-2200 Copenhagen N, Denmark Rigshosp, Copenhagen Muscle Res Ctr, DK-2100 Copenhagen, Denmark RigshospCopenhagen Denmark DK-2100 Res Ctr, DK-2100 Copenhagen, Denmark Rigshosp, Dept Anesthesia, DK-2100 Copenhagen, Denmark Rigshosp Copenhagen Denmark DK-2100 sthesia, DK-2100 Copenhagen, Denmark Herlev Hosp, Dept Clin Physiol & Nucl Med, DK-2730 Herlev, Denmark Herlev Hosp Herlev Denmark DK-2730 l & Nucl Med, DK-2730 Herlev, Denmark
Titolo Testata:
DIABETES
fascicolo: 8, volume: 50, anno: 2001,
pagine: 1834 - 1843
SICI:
0012-1797(200108)50:8<1834:ISAGKD>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
ISLETS; MOBILIZATION; VOLUNTEERS; LANGERHANS; YOHIMBINE; TURNOVER; HUMANS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Dela, F Univ Copenhagen, Panum Inst, Dept Med Physiol, Blegdamsvej 3,Bldg 12-4-7, DK-2200 Copenhagen N, Denmark Univ Copenhagen Blegdamsvej 3,Bldg 12-4-7 Copenhagen Denmark N rk
Citazione:
P. Aarnio et al., "Insulin secretion and glucose kinetics during exercise with and without pharmacological alpha(1)- and alpha(2)-receptor blockade", DIABETES, 50(8), 2001, pp. 1834-1843

Abstract

The mechanism behind exercise-induced decreases in plasma insulin concentrations was examined in eight healthy young men. In addition, the influence of specific alpha (1)- and alpha (2)-adrenoceptor blockade on glucose kinetics during exercise was studied. To test the hypothesis that exercise-induced decreases in insulin secretion are mediated via alpha (2)-adrenoceptors,all subjects exercised for 60 min on separate occasions under four conditions: with and without alpha (1)-receptor blockade (1 mg prazosin) and with and without or alpha (2)-receptor blockade (15 mg yohimbine). Glucose kinetics were measured using [3-H-3]glucose. During exercise with alpha (2)-receptor blockade, the insulin concentration initially increased (first 20 min)then decreased, whereas it continually decreased in the corresponding control experiment. The C-peptide concentration did not change during exercise with alpha (2)-receptor blockade but decreased in the control experiment. During exercise with alpha (1)-receptor blockade and corresponding control experiments, insulin and C-peptide levels always decreased. With alpha (1)-receptor blockade, the glucose concentration increased (first 30 min) and then decreased, whereas it slightly decreased in all other experiments. In addition, with alpha (2)-receptor blockade, the glucose rate of appearance (Ra) increased rapidly (because of higher catecholamine concentrations in alpha (1)-receptor blockade versus control) and the glucose rate of disappearance (Rd) was higher compared with control. During exercise with alpha (2)-receptor blockade, the Ra and Rd were always lower compared with control. Therefore, we conclude that exercise-induced decreases in insulin secretion are mediated via alpha (2)-adrenoceptors and that blockade of alpha (1)- andalpha (2)-adrenoceptors during exercise elicits opposite responses in glucose Ra and Rd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 05:31:24