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Titolo:
Excess lunatic fringe causes cranial neural crest over-proliferation
Autore:
Nellemann, C; de Bellard, ME; Barembaum, M; Laufer, E; Bronner-Fraser, M;
Indirizzi:
CALTECH, Div Biol, Pasadena, CA 91125 USA CALTECH Pasadena CA USA 91125CALTECH, Div Biol, Pasadena, CA 91125 USA Columbia Univ, Dept Genet & Dev, New York, NY 10032 USA Columbia Univ NewYork NY USA 10032 t Genet & Dev, New York, NY 10032 USA
Titolo Testata:
DEVELOPMENTAL BIOLOGY
fascicolo: 1, volume: 235, anno: 2001,
pagine: 121 - 130
SICI:
0012-1606(20010701)235:1<121:ELFCCN>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
SOMITE SEGMENTATION; RETROVIRAL VECTORS; GENE-EXPRESSION; NOTCH PATHWAY; NEUROGENESIS; DELTA; CELLS; HOMOLOG; CHICK; GLIOGENESIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Bronner-Fraser, M CALTECH, Div Biol, 139-74, Pasadena, CA 91125 USA CALTECH 139-74 Pasadena CA USA 91125 adena, CA 91125 USA
Citazione:
C. Nellemann et al., "Excess lunatic fringe causes cranial neural crest over-proliferation", DEVELOP BIO, 235(1), 2001, pp. 121-130

Abstract

Lunatic fringe is a vertebrate homologue of Drosophila fringe, which playsan important role in modulating Notch signaling. This study examines the distribution of chick lunatic fringe at sites of neural crest formation and explores its possible function by ectopic expression. Shortly after neural tube closure, lunatic fringe is expressed in most of the neural tube, with the exception of the dorsal midline containing presumptive neural crest. Thus, there is a fringe/non-fringe border at the site of neural crest production. Expression of excess lunatic fringe in the cranial neural tube and neural crest by retrovirally mediated gene transfer resulted in a significant increase (similar to 60%) in the percentage of cranial neural crest cells 1day after infection. This effect was mediated by an increase in cell division as assayed by BrdU incorporation. Infected embryos had an up-regulationof Delta-1 in the dorsal neural tube and redistribution of Notch-1 to the lumen of the neural tube, confirming that excess fringe modulates Notch signaling. These findings point to a novel role for lunatic fringe in regulating cell division and/or production of neural crest cells by the neural tube. (C) 2001 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/04/20 alle ore 06:44:36