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Titolo:
Genetic polymorphisms, lipoproteins and coronary artery disease risk
Autore:
Talmud, PJ; Humphries, SE;
Indirizzi:
Royal Free & Univ Coll, Sch Med, Dept Med, Div Cardiovasc Genet, London WC1E 6JJ, England Royal Free & Univ Coll London England WC1E 6JJ London WC1E 6JJ, England
Titolo Testata:
CURRENT OPINION IN LIPIDOLOGY
fascicolo: 4, volume: 12, anno: 2001,
pagine: 405 - 409
SICI:
0957-9672(200108)12:4<405:GPLACA>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOW-DENSITY-LIPOPROTEIN; ISCHEMIC-HEART-DISEASE; LIPASE GENE; PLASMA-LIPIDS; MYOCARDIAL-INFARCTION; ATHEROSCLEROSIS; POPULATION; MUTATIONS; SMOKERS; VARIANTS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Talmud, PJ Royal Free & Univ Coll, Sch Med, Dept Med, Div Cardiovasc Genet, London WC1E 6JJ, England Royal Free & Univ Coll London England WC1E 6JJE 6JJ, England
Citazione:
P.J. Talmud e S.E. Humphries, "Genetic polymorphisms, lipoproteins and coronary artery disease risk", CURR OP LIP, 12(4), 2001, pp. 405-409

Abstract

Association studies between gene variants (polymorphisms) and measured intermediate phenotypes, such as lipid/ lipoprotein levels, or disease endpoints such as coronary artery disease, are commonplace in the literature. But have we learnt anything from the shortcomings in study design and analytical strategies that have resulted in much controversy in this field over the last few years? This review highlights some of these problems. Using the lipoprotein lipase gene as an example, we evaluate new approaches to identifying polymorphisms that will stand up to linkage disequilibrium/association studies with complex disorders in this post Human Genome Project age, and emphasize the importance of gene-environment interaction in assessing the impact of gene variants. Curr Opin Lipidol 12:405-409. (C) 2001 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 01:11:43