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Titolo:
Dietary carbohydrates, 'metabolic syndrome' physical inactivity, obesity, and the as predictors of coronary heart disease
Autore:
Liu, SM; Manson, JE;
Indirizzi:
Brigham & Womens Hosp, Dept Med, Div Prevent Med, Boston, MA 02215 USA Brigham & Womens Hosp Boston MA USA 02215 event Med, Boston, MA 02215 USA Harvard Univ, Sch Med, Boston, MA USA Harvard Univ Boston MA USAHarvard Univ, Sch Med, Boston, MA USA Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 th, Dept Epidemiol, Boston, MA 02115 USA Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA Harvard UnivBoston MA USA 02115 bl Hlth, Dept Nutr, Boston, MA 02115 USA
Titolo Testata:
CURRENT OPINION IN LIPIDOLOGY
fascicolo: 4, volume: 12, anno: 2001,
pagine: 395 - 404
SICI:
0957-9672(200108)12:4<395:DC'SPI>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
C-REACTIVE PROTEIN; MIDDLE-AGED MEN; CARDIOVASCULAR RISK-FACTORS; DEPENDENT DIABETIC-PATIENTS; HEALTH-CARE PROFESSIONALS; WHOLE-GRAIN CONSUMPTION; BODY-MASS INDEX; GLYCEMIC INDEX; INSULIN-RESISTANCE; COMPLEX CARBOHYDRATE;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
114
Recensione:
Indirizzi per estratti:
Indirizzo: Liu, SM Brigham & Womens Hosp, Dept Med, Div Prevent Med, 900 CommonwealthAve, Boston, MA 02215 USA Brigham & Womens Hosp 900 Commonwealth Ave Boston MA USA 02215 USA
Citazione:
S.M. Liu e J.E. Manson, "Dietary carbohydrates, 'metabolic syndrome' physical inactivity, obesity, and the as predictors of coronary heart disease", CURR OP LIP, 12(4), 2001, pp. 395-404

Abstract

Several decades of epidemiological and clinical research have identified physical inactivity, excessive calorie consumption, and excess weight as common risk factors for both type 2 diabetes mellitus and coronary heart disease. This trio forms the environmental substrate for a now well-recognized metabolic phenotype called the insulin resistance syndrome. Recent data suggest that a high intake of rapidly absorbed carbohydrates, which is characterized by a high glycemic load (a measure of carbohydrate quality and quantity), may increase the risk of coronary heart disease by aggravating glucoseintolerance and dyslipidemia. These data also suggest that individuals whoare obese and insulin resistant are particularly prone to the adverse effects of a high dietary glycemic load. In addition, data continue to accumulate suggesting the important beneficial effects of physical activity, even at moderate levels, and weight reduction on improving insulin sensitivity and reducing the risk of coronary heart disease. Future metabolic studies should continue to quantify the physiological impact of different foods on serum glucose and insulin, and such information should routinely be incorporated into large-scale and long-term prospective studies, in which the possible interaction effects between diet and other metabolic determinants such asphysical activity and obesity can be examined. Until more definitive data are available, replacing refined grain products and potatoes with minimallyprocessed plant-based foods such as whole grains, fruits, and vegetables, and reducing the intake of high glycemic load beverages may offer a simple strategy for reducing the incidence of coronary heart disease. Curr Opin Lipidol 12:395-404, (C) 2001 Lippincott Williams & Wilkins.

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Documento generato il 02/12/20 alle ore 18:12:07