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Titolo:
Polyglucosan bodies and temporal lobe epilepsy: an incidental finding or more?
Autore:
Streichenberger, N; Ryvlin, P; Guenot, M; Sindou, M; Kopp, N; Mauguiere, F;
Indirizzi:
Hop Neurol, Neuropathol Lab, Dept Neuropathol, F-69394 Lyon 03, France HopNeurol Lyon France 03 Lab, Dept Neuropathol, F-69394 Lyon 03, France Hop Neurol, Dept Epileptol, F-69394 Lyon, France Hop Neurol Lyon France F-69394 rol, Dept Epileptol, F-69394 Lyon, France Hop Neurol, Dept Neurosurg, F-69394 Lyon 03, France Hop Neurol Lyon France 03 eurol, Dept Neurosurg, F-69394 Lyon 03, France
Titolo Testata:
CLINICAL NEUROPATHOLOGY
fascicolo: 4, volume: 20, anno: 2001,
pagine: 172 - 175
SICI:
0722-5091(200107/08)20:4<172:PBATLE>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
BODY DISEASE; BRAIN;
Keywords:
corpora amylacea; epilepsy; neurosurgery; polyglucosan bodies;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
16
Recensione:
Indirizzi per estratti:
Indirizzo: Streichenberger, N Hop Neurol, Neuropathol Lab, Dept Neuropathol, BP Lyon Montchat, F-69394 Lyon 03, France Hop Neurol BP Lyon Montchat Lyon France 03 03, France
Citazione:
N. Streichenberger et al., "Polyglucosan bodies and temporal lobe epilepsy: an incidental finding or more?", CLIN NEUR, 20(4), 2001, pp. 172-175

Abstract

This study reports on histological findings in the temporal lobe of a 36-year-old woman who underwent a right temporal lobectomy for pharmaco-resistant complex partial seizures. Since surgery, the patient has remained seizure-free. The patient had an established diagnosis of right temporal robe epilepsy, based on video EEG recordings of seizures, MRI hippocampal atrophy, focal interictal hypometabolism on fluoro-desoxy-glucose, hypofixation of C-11-flumazenil in PET studies, and ictal intracerebral recordings. Biopsieswere studied under light- and electron microscopy. Histology showed diffuse distribution of a large number of polyglucosan bodies (PBs) in the whole right temporal lobe white matter. PBs were mostly confined to the perivascular areas and in subpial zones rarely and were observed in the most superficial cortical layers. There was some neuronal loss, especially in opercularzone T1. but no other histological lesion was found. Ultrastructurally, PBs were made of filamentous and amorphous material, and were found both in intra-astrocytic processes and in axons. The presence of numerous PBs in thetemporal lobe of patients with refractory temporal lobe epilepsy has been reported in 3 patients in the literature. It raises the questions whether this histological abnormality could be related to the epileptogenic process as a cause or as a consequence.

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Documento generato il 04/04/20 alle ore 15:28:11