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Titolo:
Immunogenetics and clinical aspects of Takayasu's arteritis patients in a Mexican Mestizo population
Autore:
Vargas-Alarcon, G; Flores-Dominguez, C; Hernandez-Pacheco, G; Zuniga, J; Gamboa, R; Soto, ME; Granados, J; Reyes, PA;
Indirizzi:
Inst Nacl Cardiol Ignacio Chavez, Dept Physiol, Mexico City 14080, DF, Mexico Inst Nacl Cardiol Ignacio Chavez Mexico City DF Mexico 14080 , DF, Mexico Inst Nacl Cardiol Ignacio Chavez, Dept Immunol, Mexico City, DF, Mexico Inst Nacl Cardiol Ignacio Chavez Mexico City DF Mexico City, DF, Mexico Inst Nacl Enfermedades Resp, Serv Infectol, Mexico City, DF, Mexico Inst Nacl Enfermedades Resp Mexico City DF Mexico exico City, DF, Mexico Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Dept Immunol & Rheumatol, Mexico City, DF, Mexico Inst Nacl Ciencias Med & Nutr Salvador Zubiran Mexico City DF Mexico ico
Titolo Testata:
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
fascicolo: 4, volume: 19, anno: 2001,
pagine: 439 - 443
SICI:
0392-856X(200107/08)19:4<439:IACAOT>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
HLA; ASSOCIATION; ANTIGEN; DISEASE; ALLELES;
Keywords:
major histocompatibility complex (MHC); HLA antigens; Takayasu's arteritis; Mexican Mestizo population;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Vargas-Alarcon, G Inst Nacl Cardiol Ignacio Chavez, Dept Physiol, Juan Badiano 1,Col Secc XVI, Mexico City 14080, DF, Mexico Inst Nacl Cardiol Ignacio Chavez Juan Badiano 1,Col Secc XVI Mexico City DF Mexico 14080
Citazione:
G. Vargas-Alarcon et al., "Immunogenetics and clinical aspects of Takayasu's arteritis patients in a Mexican Mestizo population", CLIN EXP RH, 19(4), 2001, pp. 439-443

Abstract

Objective The aim of the present work was to study the association betweenHLA alleles and Takayasu's arteritis in Mexican Mestizo patients. Methods The study included 26 Mexican Mestizo patients with Takayasu's arteritis and 99 healthy unrelated individuals. HLA-A, -B and -DR alleles weredetermined by polymerase chain reaction PCR-SSPResults Increased gene frequencies were demonstrated for HLA-B15 (p=0.009,pC=0.020, OR=3.24, EF=11.9%) and HLA-B52 (p=0.008, pC=0.027, OR=5.16, EF=7.7%), and a decreased frequency for the HLA-A24 allele in patients comparedto normal controls (p=0.035, pC=NS, PF=11.1%). When HLA typing was correlated to clinical features in 24 cases, we found an increased frequencies of HLA-DR14 in patients with systemic arterial hypertension (p=0.005, pC=0.004, OR=24.6 EF=38.3%) and HLA-A2 on patients with pulmonary involvement (p=0.034, pC=0.036, OR=3.67 EF=40.4%) when compared to patients without these clinical manifestations. Conclusion These data confirm HLA-B52 as a relevant susceptibility allele for Takayasu's arteritis and suggest that HLA-B15 could be important as a marker of the disease in Mexican patients. Other class I and/or class II alleles could also be relevant as markers for the clinical features present inthese patients.

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Documento generato il 31/03/20 alle ore 17:53:53