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Titolo:
Anti-beta 2 glycoprotein I and anticardiolipin antibodies in leptospirosis, syphilis and Kala-azar
Autore:
Santiago, M; Martinelli, R; Ko, A; Reis, EA; Fontes, RD; Nascimento, EG; Pierangeli, S; Espinola, R; Gharavi, A;
Indirizzi:
Hosp Santa Izabel, Escola Bahiana Med & Saude Publ, Salvador, BA, Brazil Hosp Santa Izabel Salvador BA Brazil & Saude Publ, Salvador, BA, Brazil Univ Fed Bahia, Fac Med, Salvador, BA, Brazil Univ Fed Bahia Salvador BA Brazil d Bahia, Fac Med, Salvador, BA, Brazil Fundacao Osvaldo Cruz, Ctr Pesquisas Goncalo Moniz, Salvador, BA, Brazil Fundacao Osvaldo Cruz Salvador BA Brazil alo Moniz, Salvador, BA, Brazil SESAB, DST, COAS, Salvador, BA, Brazil SESAB Salvador BA BrazilSESAB, DST, COAS, Salvador, BA, Brazil SESAB, PIEJ, Salvador, BA, Brazil SESAB Salvador BA BrazilSESAB, PIEJ, Salvador, BA, Brazil Cornell Univ, Weill Med Coll, New York, NY USA Cornell Univ New York NY USA nell Univ, Weill Med Coll, New York, NY USA Morehouse Sch Med, Atlanta, GA 30310 USA Morehouse Sch Med Atlanta GA USA30310 use Sch Med, Atlanta, GA 30310 USA
Titolo Testata:
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
fascicolo: 4, volume: 19, anno: 2001,
pagine: 425 - 430
SICI:
0392-856X(200107/08)19:4<425:A2GIAA>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
SYSTEMIC LUPUS-ERYTHEMATOSUS; BETA-2-GLYCOPROTEIN-I APOLIPOPROTEIN-H; PRIMARY ANTIPHOSPHOLIPID SYNDROME; PARVOVIRUS B19 INFECTION; ANTI-BETA(2)-GLYCOPROTEIN-I ANTIBODIES; RECOGNIZE BETA(2)-GLYCOPROTEIN-I; CARDIOLIPIN; THROMBOSIS; BINDING; AUTOANTIBODIES;
Keywords:
antiphospholipid antibodies; anticardiolipin antibodies; anti-beta 2 glycoprotein I; syphilis; leptospirosis; Kala-azar;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Santiago, M Hosp Santa Izabel, Escola Bahiana Med & Saude Publ, BR-40000000 Nazare Salvador, BA, Brazil Hosp Santa Izabel Nazare Salvador BA Brazil BR-40000000 BCzil
Citazione:
M. Santiago et al., "Anti-beta 2 glycoprotein I and anticardiolipin antibodies in leptospirosis, syphilis and Kala-azar", CLIN EXP RH, 19(4), 2001, pp. 425-430

Abstract

Objective Reports have shown that anticardiolipin (aCL) antibodies presentin patients with autoimmune diseases are dependent on the cofactor beta2 glycoprotein I (beta2 GPI), as opposed to aCL antibodies seen in infectious diseases such as syphilis, HIV hepatitis C, etc. The assay for anti-beta 2GPI antibodies has been reported to be more specific for antiphospholipid syndrome (APS). However; the prevalence of these antibodies in diseases such as leishmaniasis and leptospirosis remains unknown. The aim of the present study was determine the prevalence of antibodies to cardiolipin and to beta2GPI in patients with different infectious diseases, including leptospirosis, syphilis and leishmaniasis. Methods Samples from patients with Kala-azar (visceral leishmaniasis), syphilis or leptospirosis were tested for IgG and IgM anticardiolipin and IgG anti-beta 2GPI antibodies by ELISA. Results In patients with Kala-azar the prevalence of lgG aCL, IgM aCL and anti-beta 2GPI was 6% (2/30), 3% (1/30) and 53% (16/30), respectively. In syphilis the prevalence was 18% (14/74), 13% (10/74) and 10% (8/70), respectively. In leptospirosis the frequency of these antibodies was 23% (9/39), 10% (4/39) and 17% (6/34), respectively. There Was no statistical correlation between aCL and anti-beta 2GPI antibodies in these diseases. Discussion This study clearly shows a significant prevalence of anti-beta 2GPI antibodies in leptospirosis and leishmaniasis and syphilis. This indicates that the assay for anti-beta 2GPI antibodies should be thoroughly validated before it is introduced as a definitive tool for the diagnosis of APS, testing a larger number of sera from patients with a wider range of clinical conditions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 20:12:40