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Titolo:
Obese female SHHF/Mcc-fa(cp) rats resist antihypertensive effects of renin-angiotensin system inhibition
Autore:
Sharkey, LC; Holycross, BJ; McCune, SA; Radin, MJ;
Indirizzi:
Ohio State Univ, Dept Vet Biosci, Columbus, OH 43210 USA Ohio State Univ Columbus OH USA 43210 Vet Biosci, Columbus, OH 43210 USA Ohio State Univ, Dept Biochem Med, Columbus, OH 43210 USA Ohio State UnivColumbus OH USA 43210 Biochem Med, Columbus, OH 43210 USA Ohio State Univ, Dept Food Sci & Technol, Columbus, OH 43210 USA Ohio State Univ Columbus OH USA 43210 i & Technol, Columbus, OH 43210 USA
Titolo Testata:
CLINICAL AND EXPERIMENTAL HYPERTENSION
fascicolo: 3, volume: 23, anno: 2001,
pagine: 227 - 239
SICI:
1064-1963(200104)23:3<227:OFSRRA>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
SPONTANEOUSLY HYPERTENSIVE RATS; CARDIAC-HYPERTROPHY; BLOOD-PRESSURE; SEX; LOSARTAN; CAPTOPRIL; RECEPTORS; ENALAPRIL; THERAPY; AGE;
Keywords:
hypertension; SHHF/Mcc-fa(cp); rats; renin-angiotensin system; obesity; female; angiotensin receptor blockers; endothelin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Radin, MJ Ohio State Univ, Dept Vet Biosci, 1925 Coffey Rd, Columbus, OH 43210 USA Ohio State Univ 1925 Coffey Rd Columbus OH USA 43210 H 43210 USA
Citazione:
L.C. Sharkey et al., "Obese female SHHF/Mcc-fa(cp) rats resist antihypertensive effects of renin-angiotensin system inhibition", CLIN EXP HY, 23(3), 2001, pp. 227-239

Abstract

Gender and obesity may influence response to pharmacological modulation ofthe renin-angiotensin system. We used SHHF/Mcc-fa(cp) rats to study effectof obesity and gender on the ability of an AT(1) receptor antagonist to decrease blood pressure. After 2 weeks treatment with irbesartan (50 mg/kg), only lean and obese males showed significant decreases in blood pressure, while obese females were completely resistant. Lean females showed a trend toward lowering of pressure (p=0.06). However, irbesartan similarly shifted angiotensin II dose response curves to the right in all groups. Twelve weeks of irbesartan also failed to decrease blood pressure, but did significantly reduce heart weight in obese females. In untreated rats, obese females had lower plasma renin activity and serum angiotensin converting enzyme activity compared to lean males, while lean and obese females had increased urinary endothelin excretion. Despite an otherwise similar genetic background contributing to hyper tension and heart failure, obese females have different patterns of humoral activation compared to lean males, which may contribute to their resistance to the depressor effects of irbesartan.

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Documento generato il 28/09/20 alle ore 00:07:55