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Titolo:
Gender difference in the relationships among hyperleptinemia, hyperinsulinemia, and hypertension
Autore:
Takizawa, H; Ura, N; Saitoh, S; Wang, L; Higashiura, K; Takagi, S; Takada, M; Togashi, N; Nakano, M; Hayashi, Y; Shimamoto, K;
Indirizzi:
Sapporo Med Univ, Dept Internal Med 2, Sch Med, Chou Ku, Sapporo, Hokkaido0600061, Japan Sapporo Med Univ Sapporo Hokkaido Japan 0600061 o, Hokkaido0600061, Japan
Titolo Testata:
CLINICAL AND EXPERIMENTAL HYPERTENSION
fascicolo: 4, volume: 23, anno: 2001,
pagine: 357 - 368
SICI:
1064-1963(200105)23:4<357:GDITRA>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
OBESE GENE-PRODUCT; INSULIN-RESISTANCE; BLOOD-PRESSURE; PLASMA LEPTIN; METABOLIC SYNDROME; LIPID-METABOLISM; SERUM LEPTIN; EXPRESSION; WEIGHT; FAT;
Keywords:
leptin; hypertension; insulin resistance; insulin-resistant hypertension; gender difference;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Takizawa, H Sapporo Med Univ, Dept Internal Med 2, Sch Med, Chou Ku, S-1,W-16, Sapporo, Hokkaido 0600061, Japan Sapporo Med Univ S-1,W-16 Sapporo Hokkaido Japan 0600061 Japan
Citazione:
H. Takizawa et al., "Gender difference in the relationships among hyperleptinemia, hyperinsulinemia, and hypertension", CLIN EXP HY, 23(4), 2001, pp. 357-368

Abstract

Studies reveals that plasma leptin levels (LEP) in females are higher thanthose in males, and that LEP in hypertensive subjects are higher than those in BMI-matched normotensive subjects. To investigate the relationships among LEP, blood pressure (BP) and insulin sensitivity, we studied these relationships in 133 Japanese males and 263 females. LEP were positively correlated with BP, body mass index, body fat mass (FM) and homeostasis model assessment (HOMA). Regression analysis in which age and FM were adjusted showed LEP were associated with BP and HOMA. Even with adjustment by age, FM andHOMA, LEP were still positively correlated BP in males. LEP in insulin-resistant hypertensives was significantly higher than those in insulin-sensitive hypertensives, in insulin-sensitive normotensives and in insulin-resistant normotensives in males. However, in females, a significantly higher LEP was observed in insulin-resistant subjects than in insulin-sensitive subjects regardless of hypertension. These data suggest that it would be sexual difference in the relationships among hyperleptinemia. hyperinsulinemia and hypertension.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 01:29:27