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Titolo:
Genetic locus in mice that blocks development of atherosclerosis despite extreme hyperlipidemia
Autore:
Mehrabian, M; Wong, J; Wang, XP; Jiang, ZM; Shi, WB; Fogelman, AM; Lusis, AJ;
Indirizzi:
Univ Calif Los Angeles, Dept Med, CHS 47 143, Los Angeles, CA 90095 USA Univ Calif Los Angeles Los Angeles CA USA 90095 Los Angeles, CA 90095 USA Univ Calif Los Angeles, Dept Microbiol Mol Genet & Immunol, Los Angeles, CA 90095 USA Univ Calif Los Angeles Los Angeles CA USA 90095 Los Angeles, CA 90095 USA Univ Calif Los Angeles, Dept Human Genet, Los Angeles, CA 90095 USA Univ Calif Los Angeles Los Angeles CA USA 90095 Los Angeles, CA 90095 USA Univ Calif Los Angeles, Inst Mol Biol, Los Angeles, CA 90095 USA Univ Calif Los Angeles Los Angeles CA USA 90095 Los Angeles, CA 90095 USA
Titolo Testata:
CIRCULATION RESEARCH
fascicolo: 2, volume: 89, anno: 2001,
pagine: 125 - 130
SICI:
0009-7330(20010720)89:2<125:GLIMTB>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
E-DEFICIENT MICE; APOLIPOPROTEIN-E; MOUSE MODEL; SUSCEPTIBILITY; HYPERCHOLESTEROLEMIA; LIPOPROTEINS; METABOLISM; CELLS; FAT;
Keywords:
congenic strains; insulin; peroxisome proliferator-activated receptor-gamma; bone marrow transplantation; quantitative trait locus;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Lusis, AJ Univ Calif Los Angeles, Dept Med, CHS 47 143, Los Angeles, CA 90095 USA Univ Calif Los Angeles Los Angeles CA USA 90095 s, CA 90095 USA
Citazione:
M. Mehrabian et al., "Genetic locus in mice that blocks development of atherosclerosis despite extreme hyperlipidemia", CIRCUL RES, 89(2), 2001, pp. 125-130

Abstract

The genes contributing to the common forms of atherosclerosis are largely unknown. One approach to dissecting complex traits such as atherosclerosis is to use animal models, such as the mouse, to map and characterize the genetic loci involved. We now report the identification of a locus for aortic lesion formation on mouse chromosome 6 that exhibits a highly significant lod score of 6.7 in a genetic cross between the susceptible strain, C57BL/6J, and the resistant strain, CAST/Ei. The locus was confirmed by constructing a congenic strain in which the chromosome 6 segment from CAST/Ei was transferred to a C57BL/6J background in a series of backcrosses. The congenic strain was almost completely resistant to diet-induced atherosclerosis. The chromosome 6 segment was also transferred onto the background of an LDL receptor-null mutation and resulted again in almost complete resistance to aortic lesion formation. This locus also influenced insulin levels but did notaffect plasma lipoprotein levels, blood pressure, or body fat. The chromosome 6 gene, which we call Artles (for arterial lesions), did not affect endothelial cell responses to oxidized LDL, but lesion formation was partiallyreduced through bone marrow transplantation. The locus contains the candidate gene peroxisome proliferator-activated receptor-gamma, and the congenicmice exhibited significantly reduced expression of peroxisome proliferator-activated receptor-gamma.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 09:30:45