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Titolo:
Vascular endothelial growth factor-B-deficient mice display an atrial conduction defect
Autore:
Aase, K; von Euler, G; Li, X; Ponten, A; Thoren, P; Cao, R; Cao, Y; Olofsson, B; Gebre-Medhin, S; Pekny, M; Alitalo, K; Betsholtz, C; Eriksson, U;
Indirizzi:
Ludwig Inst Canc Res, Stockholm Branch, S-17177 Stockholm, Sweden Ludwig Inst Canc Res Stockholm Sweden S-17177 S-17177 Stockholm, Sweden Karolinska Inst, Dept Physiol & Pharmacol, Sect Integrat Cardiovasc Physiol, Stockholm, Sweden Karolinska Inst Stockholm Sweden Cardiovasc Physiol, Stockholm, Sweden Karolinska Inst, Sect Angiogenesis Res, Microbiol & Tumorbiol Ctr, Stockholm, Sweden Karolinska Inst Stockholm Sweden iol & Tumorbiol Ctr, Stockholm, Sweden Univ Gothenburg, Dept Biochem Med, Gothenburg, Sweden Univ Gothenburg Gothenburg Sweden Dept Biochem Med, Gothenburg, Sweden Univ Helsinki, Haartman Inst, Mol Canc Biol Lab, Helsinki, Finland Univ Helsinki Helsinki Finland st, Mol Canc Biol Lab, Helsinki, Finland
Titolo Testata:
CIRCULATION
fascicolo: 3, volume: 104, anno: 2001,
pagine: 358 - 364
SICI:
0009-7322(20010717)104:3<358:VEGFMD>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
TYROSINE KINASE; VEGF-B; FLT-1 RECEPTOR; IN-VIVO; MOUSE; EXPRESSION; ANGIOGENESIS; LIGAND; NEUROPILIN-1; SUGGESTS;
Keywords:
growth substances; angiogenesis; electrocardiography; atrium; conduction;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Eriksson, U Ludwig Inst Canc Res, Stockholm Branch, Box 240, S-17177 Stockholm, Sweden Ludwig Inst Canc Res Box 240 Stockholm Sweden S-17177 Sweden
Citazione:
K. Aase et al., "Vascular endothelial growth factor-B-deficient mice display an atrial conduction defect", CIRCULATION, 104(3), 2001, pp. 358-364

Abstract

Background - Vascular endothelial growth factors (VEGFs) and their receptors are essential regulators of vasculogenesis and angiogenesis in both embryos and adults. One of the factors with a still unknown physiological function is VEGF-B, which is expressed in many tissues, including the heart. Methods and Results - Mice carrying a targeted deletion in the VEGF-B genewere developed. In VEGF-B animals, no gross abnormalities were observed inorgans that normally show high expression of VEGF-B, such as the heart, muscle, and kidney. Analysis of heart function by ECG showed that adult VEGF-B-/- mice have an atrial conduction abnormality characterized by a prolonged PQ interval. VEGF- or basic fibroblast growth factor-induced corneal angiogenesis was similar in normal and VEGF-B-/- mice. Conclusions - VEGF-B seems to be required for normal heart function in adult animals but is not required for proper development of the cardiovascularsystem either during development or for angiogenesis in adults.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 21:33:17