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Titolo:
Determination of new beta(2)-agonist drugs by alpha(1)-acid glycoprotein affinity chromatography
Autore:
Gallo, P; Brambilla, G; Fiori, M; Scaramuzzo, A; Serpe, L;
Indirizzi:
Ist Zooprofilatt Sperimentale Mezzogiorno, I-80055 Portici, NA, Italy Ist Zooprofilatt Sperimentale Mezzogiorno Portici NA Italy I-80055 Italy Ist Super Sanita, Lab Med Vet, I-00161 Rome, Italy Ist Super Sanita RomeItaly I-00161 ta, Lab Med Vet, I-00161 Rome, Italy
Titolo Testata:
CHROMATOGRAPHIA
, volume: 53, anno: 2001,
parte:, 2 supplemento:, S
pagine: S446 - S449
SICI:
0009-5893(2001)53:<S446:DONBDB>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
LIQUID-CHROMATOGRAPHY; CLENBUTEROL; CLEANUP;
Keywords:
affinity chromatography; adrenergic drugs; alpha(1)-acid glycoprotein;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Physical, Chemical & Earth Sciences
Citazioni:
9
Recensione:
Indirizzi per estratti:
Indirizzo: Gallo, P Ist Zooprofilatt Sperimentale Mezzogiorno, Via Salute 2, I-80055 Portici, NA, Italy Ist Zooprofilatt Sperimentale Mezzogiorno Via Salute 2 Portici NA Italy I-80055
Citazione:
P. Gallo et al., "Determination of new beta(2)-agonist drugs by alpha(1)-acid glycoprotein affinity chromatography", CHROMATOGR, 53, 2001, pp. S446-S449

Abstract

The illicit use of new beta (2)-agonist drugs in meat production is prompting the European Union to improve analytical techniques and testing methods, to authoritatively demonstrate the abuse of such compounds. In this paper, we describe the preparation of xi-acid glycoprotein (AAG) columns for purification by affinity chromatography of clenbuterol and new beta (2)-agonists from bovine urine. HPLC-UV/DAD analyses showed no significant matrix interference in binding, thus indicating the specificity of such a clean-up procedure. Such AAG columns were able to effectively bind a broader range of beta (2)-agonists, compared to immuno-affinity columns. Our approach could improve the clean-up step within a multi-residue analytical strategy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 02:54:56