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Titolo:
The cannabinoid receptor agonist WIN 55,212-2 regulates glutamate transmission in rat cerebral cortex: an in vivo and in vitro study
Autore:
Ferraro, L; Tomasini, MC; Gessa, GL; Bebe, BW; Tanganelli, S; Antonelli, T;
Indirizzi:
Univ Ferrara, Pharmacol Sect, Dept Clin & Expt Med, I-44100 Ferrara, ItalyUniv Ferrara Ferrara Italy I-44100 in & Expt Med, I-44100 Ferrara, Italy Univ Cagliari, Dept Neurosci, Cagliari, Italy Univ Cagliari Cagliari Italy v Cagliari, Dept Neurosci, Cagliari, Italy
Titolo Testata:
CEREBRAL CORTEX
fascicolo: 8, volume: 11, anno: 2001,
pagine: 728 - 733
SICI:
1047-3211(200108)11:8<728:TCRAW5>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
PREFRONTAL CORTEX; WORKING-MEMORY; CB1 RECEPTOR; ACETYLCHOLINE-RELEASE; SYNAPTIC TRANSMISSION; NG108-15 CELLS; AMINO-ACIDS; BRAIN; CA2+; NEURONS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Tanganelli, S Univ Ferrara, Pharmacol Sect, Dept Clin & Expt Med, Via Fossato Mortara 17-19, I-44100 Ferrara, Italy Univ Ferrara Via Fossato Mortara 17-19 Ferrara Italy I-44100
Citazione:
L. Ferraro et al., "The cannabinoid receptor agonist WIN 55,212-2 regulates glutamate transmission in rat cerebral cortex: an in vivo and in vitro study", CEREB CORT, 11(8), 2001, pp. 728-733

Abstract

The effects of the cannahinoid receptor agonist WIN 55,212-2 on endogenousextracellular glutamate levels in the prefrontal cortex of the awake rat and in primary cultures of rat cerebral cortex neurons were investigated. Inthe prefrontal cortex WIN 55,212-2 (0.1 and 1 mg/kg i.p.) increased dialysate glutamate levels from of the awake rat, while the lower (0.01 mg/kg) and the higher (2 mg/kg) doses were ineffective. Furthermore, the WIN 55,212-2 (0.1 mg/kg)induced increase of dialysate glutamate levels was counteracted by pretreatment with the selective CB1 receptor antagonist SR141716A (0.1mg/kg i.p.) and by the local perfusion with a low-calcium Ringer solution (Ca2+ 0.2 mM), In primary cultures of rat cerebral cortex neurons, WIN 55,212-2 (0.01-100 nM) increased extracellular glutamate levels, displaying a bell-shaped concentration-response curve. The facilitatory effect of WIN 55,212-2 (1 nM) was fully counteracted by SR141716A (10 nM), by the replacement of the normal Krebs Ringer-bicarbonate buffer with a low Ca2+ medium (0.2mM) and by the IP3 receptor antagonist xestospongin C (1 muM). These in vivo and in vitro findings suggest an increase in cortical glutamatergic transmission by CB1 receptors, an effect that may underlie some of the psychoactive and behavioural actions of acute exposure to marijuana.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/04/20 alle ore 09:02:56