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Titolo:
Juvenile emotional experience alters synaptic inputs on pyramidal neurons in the anterior cingulate cortex
Autore:
Helmeke, C; Ovtscharoff, W; Poeggel, G; Braun, K;
Indirizzi:
Leibniz Inst Neurobiol, D-39008 Magdeburg, Germany Leibniz Inst NeurobiolMagdeburg Germany D-39008 9008 Magdeburg, Germany Univ Leipzig, Dept Human Biol, D-04103 Leipzig, Germany Univ Leipzig Leipzig Germany D-04103 uman Biol, D-04103 Leipzig, Germany
Titolo Testata:
CEREBRAL CORTEX
fascicolo: 8, volume: 11, anno: 2001,
pagine: 717 - 727
SICI:
1047-3211(200108)11:8<717:JEEASI>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
RODENT OCTODON-DEGUS; DIAPHORASE-REACTIVE NEURONS; MEDIAL PREFRONTAL CORTEX; EARLY SOCIAL DEPRIVATION; SIZED SPINY NEURONS; RAT VISUAL-CORTEX; DENDRITIC SPINES; QUANTITATIVE CHANGES; MATERNAL SEPARATION; INTERGENICULATE LEAFLET;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
101
Recensione:
Indirizzi per estratti:
Indirizzo: Braun, K Leibniz Inst Neurobiol, Brenneckestr 6, D-39118 Magdeburg, Germany Leibniz Inst Neurobiol Brenneckestr 6 Magdeburg Germany D-39118
Citazione:
C. Helmeke et al., "Juvenile emotional experience alters synaptic inputs on pyramidal neurons in the anterior cingulate cortex", CEREB CORT, 11(8), 2001, pp. 717-727

Abstract

Analogous to the experience-driven development of sensory systems, the functional maturation of limbic circuits is significantly influenced by early socio-emotional experience. In a combined light and electron microscopic study in the anterior cingulate cortex of Octodon degus, the densities of spine and shaft synapses on apical dendrites of layer III pyramidal neurons were compared in 45 day old (1) undisturbed control animals; (2) handled animals; (3) animals which were repeatedly maternally deprived during the firstthree postnatal weeks; (4) animals which were treated similarly to group 3and thereafter kept in chronic social isolation. Animals in groups 2-4 showed significantly higher spine densities (up to 121%. 142% and 151% respectively) compared to control group 1. Group 3 displayed significantly longer apical dendrites compared to control group 1. The electron microscopic analysis in cortical layer II revealed significantly higher spine synapses in group 4 (up to 166%) and fewer shaft synapses in groups 3 and 4 (down to 53%and 65% respectively) compared to group 1. These results demonstrate that early traumatic emotional experience alters synaptic input of pyramidal neurons. Such experience-induced modulation of limbic cortex development may determine psychosocial and cognitive capacities during later life.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 01:01:01