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Titolo:
Regulatory RNAs
Autore:
Erdmann, VA; Barciszewska, MZ; Hochberg, A; de Groot, N; Barciszewski, J;
Indirizzi:
Free Univ Berlin, Inst Biochem, D-14195 Berlin, Germany Free Univ Berlin Berlin Germany D-14195 Biochem, D-14195 Berlin, Germany Polish Acad Sci, Inst Bioorgan Chem, PL-61704 Poznan, Poland Polish Acad Sci Poznan Poland PL-61704 gan Chem, PL-61704 Poznan, Poland Hebrew Univ Jerusalem, Inst Life Sci, Dept Biol Chem, IL-91904 Jerusalem, Israel Hebrew Univ Jerusalem Jerusalem Israel IL-91904 -91904 Jerusalem, Israel
Titolo Testata:
CELLULAR AND MOLECULAR LIFE SCIENCES
fascicolo: 7, volume: 58, anno: 2001,
pagine: 960 - 977
SICI:
1420-682X(200106)58:7<960:RR>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
X-CHROMOSOME INACTIVATION; BECKWITH-WIEDEMANN-SYNDROME; IMPRINTED ANTISENSE RNA; PROSTATE-SPECIFIC GENE; HAMSTER HA-1 CELLS; OPEN READING FRAME; ESCHERICHIA-COLI; MESSENGER-RNA; DOSAGE COMPENSATION; CAENORHABDITIS-ELEGANS;
Keywords:
non-coding RNA; antisense RNA; regulatory RNA;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
179
Recensione:
Indirizzi per estratti:
Indirizzo: Barciszewski, J Free Univ Berlin, Inst Biochem, Thielallee 63, D-14195 Berlin, Germany Free Univ Berlin Thielallee 63 Berlin Germany D-14195 any
Citazione:
V.A. Erdmann et al., "Regulatory RNAs", CELL MOL L, 58(7), 2001, pp. 960-977

Abstract

In addition to mRNA, rRNA and tRNA, which play central roles within cells,there are a number of regulatory, non-coding RNAs (ncRNAs). Of varying lengths, ncRNAs have no long open reading frame. While not encoding proteins, they may act as riboregulators, and their main function is posttranscriptional regulation of gene expression. Many ncRNAs have been identified and characterized both in prokaryotes and eukaryotes, and are involved in the specific recognition of cellular nucleic acid targets through complementary base pairing, controlling cell growth and differentiation. Some are associatedwith the abnormalities in imprinted inheritance that occur in several well-known developmental and neurobehavioral disorders. Other ncRNAs accomplishregulation by modulating the activity of proteins. Several rRNAs are able to sustain enzymatic reactions implicated in the translation process including synthesis of peptide bonds within the ribosome. The different roles played by widely distributed RNAs acting in diverse ways, suggest the flexibility and versality of these molecules in regulatory processes. This review summarizes the available biochemical and structural data on known regulatoryRNAs.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 12:44:00