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Titolo:
AMPA receptors: potential implications in development and disease
Autore:
Franciosi, S;
Indirizzi:
Univ British Columbia, Fac Med, Dept Pharmacol & Therapeut, Vancouver, BC V6T 1Z3, Canada Univ British Columbia Vancouver BC Canada V6T 1Z3 ver, BC V6T 1Z3, Canada
Titolo Testata:
CELLULAR AND MOLECULAR LIFE SCIENCES
fascicolo: 7, volume: 58, anno: 2001,
pagine: 921 - 930
SICI:
1420-682X(200106)58:7<921:ARPIID>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM POTENTIATION; METHYL-D-ASPARTATE; CENTRAL-NERVOUS-SYSTEM; AMINO-ACID RECEPTORS; SELECTIVE GLUTAMATE RECEPTORS; CULTURED HIPPOCAMPAL-NEURONS; DOMAIN-CONTAINING PROTEIN; GLIAL PROGENITOR CELLS; DEVELOPING RAT-BRAIN; AGE-RELATED-CHANGES;
Keywords:
AMPA; NMDA; electrophysiology; long-term potentiation; calcium; neurological disorders;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
123
Recensione:
Indirizzi per estratti:
Indirizzo: Franciosi, S Univ British Columbia, Fac Med, Dept Pharmacol & Therapeut, 2176 Hlth Sci Mall, Vancouver, BC V6T 1Z3, Canada Univ British Columbia 2176Hlth Sci Mall Vancouver BC Canada V6T 1Z3
Citazione:
S. Franciosi, "AMPA receptors: potential implications in development and disease", CELL MOL L, 58(7), 2001, pp. 921-930

Abstract

alpha -amino-3-hydroxy-5-methyl-4-isoxazoleproprionic acid (AMPA) receptors are one type of ionotropic glutamate receptor involved in rapid excitatory synaptic transmission. AMPA receptors have been increasingly implicated in long-term potentiation, and recent evidence suggests that they may play arole in disorders affecting the nervous system. The finding that early in postnatal development AMPA receptors are not expressed has lately been the focus of much attention. Resolving the factors involved in AMPA receptor expression suggests that their induction is a developmentally regulated process with the possibility that alterations in receptor expression may be correlated with pathology in neurological disorders. This paper provides an overview of factors involved in AMPA receptor induction as well as of their role in plasticity and neuronal pathologies.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 19:13:21