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Titolo:
Multifunctional alpha-enolase: its role in diseases
Autore:
Pancholi, V;
Indirizzi:
Rockefeller Univ, Lab Bacterial Pathogenesis & Immunol, New York, NY 10021USA Rockefeller Univ New York NY USA 10021 s & Immunol, New York, NY 10021USA
Titolo Testata:
CELLULAR AND MOLECULAR LIFE SCIENCES
fascicolo: 7, volume: 58, anno: 2001,
pagine: 902 - 920
SICI:
1420-682X(200106)58:7<902:MAIRID>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEURON-SPECIFIC ENOLASE; CANDIDATE PLASMINOGEN RECEPTOR; CANCER-ASSOCIATED RETINOPATHY; GLYCOLYTIC ENZYME ENOLASE; HEAT-SHOCK PROTEINS; C-MYC PROMOTER; YEAST ENOLASE; GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE; CRYSTAL-STRUCTURE; BINDING-PROTEIN;
Keywords:
enolase; autoimmunity; rheumatic fever; SLE;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
119
Recensione:
Indirizzi per estratti:
Indirizzo: Pancholi, V Rockefeller Univ, Lab Bacterial Pathogenesis & Immunol, 1230 York Ave, NewYork, NY 10021 USA Rockefeller Univ 1230 York Ave New York NY USA 10021 10021 USA
Citazione:
V. Pancholi, "Multifunctional alpha-enolase: its role in diseases", CELL MOL L, 58(7), 2001, pp. 902-920

Abstract

Enolase, a key glycolytic enzyme, belongs to a novel class of surface proteins which do not possess classical machinery for surface transport, yet through an unknown mechanism are transported on the cell surface. Enolase is a multifunctional protein, and its ability to serve as a plasminogen receptor on the surface of a variety of hematopoetic, epithelial and endothelial cells suggests that it may play an important role in the intravascular and pericellular fibrinolytic system. Its role in systemic and invasive autoimmune disorders was recognized only very recently. In addition to this property, its ability to function as a heat-shock protein and to bind cytoskeletal and chromatin structures indicate that enolase may play a crucial role intranscription and a variety of pathophysiological processes.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/06/20 alle ore 00:00:10