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Titolo:
Structural studies of discoidal lipoprotein A-I
Autore:
Koppaka, V;
Indirizzi:
Univ Penn, Dept Pharmacol, Philadelphia, PA 19104 USA Univ Penn Philadelphia PA USA 19104 Pharmacol, Philadelphia, PA 19104 USA
Titolo Testata:
CELLULAR AND MOLECULAR LIFE SCIENCES
fascicolo: 7, volume: 58, anno: 2001,
pagine: 885 - 893
SICI:
1420-682X(200106)58:7<885:SSODLA>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
HIGH-DENSITY-LIPOPROTEIN; LECITHIN-CHOLESTEROL-ACYLTRANSFERASE; BINDING CASSETTE TRANSPORTER-1; LIPID-FREE STRUCTURE; RECEPTOR SR-BI; PLASMA-LIPOPROTEINS; TANGIER-DISEASE; INFRARED-SPECTROSCOPY; AMPHIPATHIC HELIX; PRE-BETA;
Keywords:
ApoA-I; belt; picket-fence; PATIR-FTIR; orientation;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
94
Recensione:
Indirizzi per estratti:
Indirizzo: Koppaka, V Univ Penn, Dept Pharmacol, 3620 Hmailton Walk, Philadelphia, PA19104 USA Univ Penn 3620 Hmailton Walk Philadelphia PA USA 19104 9104 USA
Citazione:
V. Koppaka, "Structural studies of discoidal lipoprotein A-I", CELL MOL L, 58(7), 2001, pp. 885-893

Abstract

Apolipoprotein A-I (apoA-I) is a major exchangeable apolipoprotein of high-density lipoproteins (HDLs), and plays an important role in reverse cholesterol transport. This process involves transport of cholesterol from peripheral tissues to the liver for processing, thereby eliminating excess cholesterol from the body. The function of apoA-I and its interaction with other components of HDL, including lecithin-cholesterol acyltransferase, seems tobe closely linked to its structural plasticity. ApoA-I is likely to undergo changes in its structure and orientation between the various HDL subclasses and therefore, knowledge of the precise structure of apoA-I is essentialfor understanding its role in the antiatherogenic properties of HDL. This review focuses on the role of apoA-I in reverse cholesterol transport and the work done by various groups to determine the structure of apoA-I in discoidal HDL particles.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 02:43:42