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Titolo:
Sex differences in brainstem neural activation after injury to the TMJ region
Autore:
Bereiter, DA;
Indirizzi:
Brown Univ, Rhode Isl Hosp, Sch Med, Dept Surg, Providence, RI 02903 USA Brown Univ Providence RI USA 02903 d, Dept Surg, Providence, RI 02903 USA Brown Univ, Rhode Isl Hosp, Sch Med, Dept Neurosci, Providence, RI 02903 USA Brown Univ Providence RI USA 02903 ept Neurosci, Providence, RI 02903 USA
Titolo Testata:
CELLS TISSUES ORGANS
fascicolo: 3, volume: 169, anno: 2001,
pagine: 226 - 237
SICI:
1422-6405(2001)169:3<226:SDIBNA>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
FOS-LIKE IMMUNOREACTIVITY; SPINAL TRIGEMINAL NUCLEUS; PAINFUL TEMPOROMANDIBULAR DISORDERS; PREPROENKEPHALIN MESSENGER-RNA; PROTEIN-LIKE IMMUNOREACTIVITY; EXPERIMENTALLY EVOKED PAIN; CERVICAL PRIMARY AFFERENTS; CENTRAL-NERVOUS-SYSTEM; MEDULLARY DORSAL HORN; IMMUNOHISTOCHEMICAL LOCALIZATION;
Keywords:
cervical spinal cord; c-fos gene; sex differences; temporomandibular joint; trigeminal spinal nucleus;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
52
Recensione:
Indirizzi per estratti:
Indirizzo: Bereiter, DA Brown Univ, Rhode Isl Hosp, Sch Med, Dept Surg, 222 Nursing Arts Bldg, Providence, RI 02903 USA Brown Univ 222 Nursing Arts Bldg Providence RI USA 02903 USA
Citazione:
D.A. Bereiter, "Sex differences in brainstem neural activation after injury to the TMJ region", CELLS T ORG, 169(3), 2001, pp. 226-237

Abstract

The basis for a higher prevalence of painful temporomandibular disorders (TMD) among women than men is not known. The present study used Fos-like immunoreactivity (Fos-LI) to quantify the pattern and magnitude of neural activation within the trigeminal brainstem complex of male and female rats caused by acute inflammatory injury to the temporomandibular joint (TMJ) region. Also, Fos-LI was assessed in animals given morphine, a preferential mu opioid receptor agonist, or U50,488H, a selective kappa opioid agonist, priorto TMJ injury to determine if opioid modulation of neural activation was similar in males and females. The general pattern of Fos-LI after TMJ injurywas similar in males and females. This pattern was characterized by a highdensity of Fos-positive neurons in the dorsal paratrigeminal nucleus (dPa5), subnucleus interpolaris/caudalis transition region (Vi/Vc-vl), and in the superficial laminae at the subnucleus caudalis/upper cervical spinal cord(Vc/C2) junction ipsilateral to TMJ injury. In contrast to other regions the number of Fos-positive neurons produced at the Vc/C2 junction was proportional to the concentration of mustard oil injected into the TMJ region. Inaddition, proestrus females produced higher levels of Fos-LI at the Vc/C2 junction than diestrus females or males. Morphine caused a greater dose-related reduction in Fos-LI at the dPa5 and Vc/C2 junction in males than females. By contrast, U50,488H caused a dose-related reduction in Fos-LI only atthe Vc/C2 junction of proestrus females. These results support the hypothesis that the Vc/C2 junction region plays a critical role in the integrationof pain signals originating from the TMJ region and may underlie sex differences in sensory processing related to TMJ pain. Copyright (C) 2001 S. Karger AG, Basel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 09:29:36