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Titolo:
Pharmacokinetics of orbifloxacin and its concentration in body fluids and in endometrial tissues of mares
Autore:
Haines, GR; Brown, MP; Gronwall, RR; Merritt, KA; Baltzley, LK;
Indirizzi:
Univ Florida, Coll Vet Med, Dept Large Anim Clin Sci, Gainesville, FL 32610 USA Univ Florida Gainesville FL USA 32610 Clin Sci, Gainesville, FL 32610 USA
Titolo Testata:
CANADIAN JOURNAL OF VETERINARY RESEARCH-REVUE CANADIENNE DE RECHERCHE VETERINAIRE
fascicolo: 3, volume: 65, anno: 2001,
pagine: 181 - 187
SICI:
0830-9000(200107)65:3<181:POOAIC>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
ARTICULAR CARTILAGES; ANTIMICROBIAL SUSCEPTIBILITY; ADULT HORSES; PHARMACODYNAMICS; FLUOROQUINOLONE; ENROFLOXACIN; CIPROFLOXACIN; MODEL; DOGS; DIFLOXACIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Brown, MP Univ Florida, Coll Vet Med, Dept Large Anim Clin Sci, Gainesville, FL 32610 USA Univ Florida Gainesville FL USA 32610 Gainesville, FL 32610 USA
Citazione:
G.R. Haines et al., "Pharmacokinetics of orbifloxacin and its concentration in body fluids and in endometrial tissues of mares", CAN J VET R, 65(3), 2001, pp. 181-187

Abstract

Pharmacokinetics and distribution of orbifloxacin into body fluids and endometrium was studied in 6 mares after intragastric (IG) administration at asingle dose rate of 7.5 mg/kg body weight. Orbifloxacin concentrations were serially measured in serum, synovial fluid, peritoneal fluid, urine, cerebrospinal fluid, and endometrial tissues over 24 hours. Minimum inhibitory concentrations of orbifloxacin were determined for 120 equine pathogens over an Ii-month period. The mean peak serum concentration (C-max) was 2.41 +/- 0.30 mug/mL at 1.5 hours after administration and decreased to 0.17 +/- 0.01 mug/mL (C-min) at 24 hours. The mean elimination half-life (t(1/2)) was9.06 +/- 1.33 hours and area under the serum concentration vs time curve (AUC) was 20.54 +/- 1.70 mg.h/L. Highest mean peritoneal fluid concentrationwas 2.15 +/- 0.49 mug/mL at 2 hours. Highest mean synovial fluid concentration was 1.17 +/- 0.28 mug/mL at 4 hours. Highest mean urine concentration was 536.67 +/- 244.79 mug/mL at 2 hours. Highest mean endometrial concentration was 0.72 +/- 0.23 mug/g at 1.5 hours. Mean CSF concentration was 0.46 /- 0.55 mug/mL at 3 hours. The minimum inhibitory concentration of orbifloxacin required to inhibit 90% of isolates (MIC90) ranged from less than or equal to 0.12 to > 8.0 mug/mL, with gram-negative organisms being more sensitive than gram-positive organisms. Orbifloxacin was uniformly absorbed in the 6 mares and was well distributed into body fluids and endometrial tissue. At a dosage of 7.5 mg/kg once a day, many gram-negative pathogens, such as Actinobacillus equuli, Escherichia coli, Pasteurella spp., and Salmonella spp. would be expected to be susceptible to orbifloxacin.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 07:28:16