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Titolo:
Prostate-specific antigen (PSA/hK3): a further player in the field of breast cancer diagnostics?
Autore:
Mannello, F; Gazzanelli, G;
Indirizzi:
Libera Univ Studi, Fac Sci MFN, Ist Istol & Anal Lab, I-61029 Urbino, PU, Italy Libera Univ Studi Urbino PU Italy I-61029 Lab, I-61029 Urbino, PU, Italy
Titolo Testata:
BREAST CANCER RESEARCH
fascicolo: 4, volume: 3, anno: 2001,
pagine: 238 - 243
SICI:
1465-542X(2001)3:4<238:PA(AFP>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
STEROID-HORMONE REGULATION; FEMALE BREAST; CELL-LINES; NIPPLE ASPIRATE; ULTRASTRUCTURAL-LOCALIZATION; PROGNOSTIC FACTORS; MOLECULAR-FORMS; MESSENGER-RNA; CYST FLUID; EXPRESSION;
Keywords:
breast; breast cyst fluid; cancer; nipple aspirate fluid; prostate-specific antigen;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Mannello, F Libera Univ Studi, Fac Sci MFN, Ist Istol & Anal Lab, Via Zeppi, I-61029 Urbino, PU, Italy Libera Univ Studi Via Zeppi Urbino PU Italy I-61029 PU, Italy
Citazione:
F. Mannello e G. Gazzanelli, "Prostate-specific antigen (PSA/hK3): a further player in the field of breast cancer diagnostics?", BREAST CA R, 3(4), 2001, pp. 238-243

Abstract

Since its identification, much information has been obtained about prostate-specific antigen (PSA, or human glandular kallikrein 3 [hK3]), a kallikrein-like serine protease that is the most valuable tumour marker for the screening, diagnosis and management of human prostate carcinoma. Recently, it has become widely accepted that PSA is also present in many nonprostatic sources, casting doubts about the specificity of its tissue expression. Here we summarize the findings on the biomolecular expression of PSA in breast secretions, cells and tissues of healthy and diseased females. Although several studies have strongly suggested that the molecular forms of PSA seem torepresent a potential tool for the risk assessment of breast cancer, recent reports have yielded conflicting results. Although several studies have suggested new biological function(s) for PSA in breast physiopathology, morestudies are needed to enlist PSA unequivocally as an additional weapon in the anticancer armoury in breast cancer diagnostics.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 00:02:20