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Titolo:
Tumour-stromal interactions - Role of the stroma in mammary development
Autore:
Silberstein, GB;
Indirizzi:
Univ Calif Santa Cruz, Dept Cell Mol & Dev Biol, Santa Cruz, CA 95064 USA Univ Calif Santa Cruz Santa Cruz CA USA 95064 l, Santa Cruz, CA 95064 USA
Titolo Testata:
BREAST CANCER RESEARCH
fascicolo: 4, volume: 3, anno: 2001,
pagine: 218 - 223
SICI:
1465-542X(2001)3:4<218:TI-ROT>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLAND DEVELOPMENT; EXTRACELLULAR-MATRIX; MOUSE; GROWTH; MORPHOGENESIS; DIFFERENTIATION; EPITHELIUM; INTEGRINS; DUCTS;
Keywords:
branching; mammary; morphogenesis; stroma; TGF-beta;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Silberstein, GB Univ Calif Santa Cruz, Dept Cell Mol & Dev Biol, Santa Cruz, CA 95064 USA Univ Calif Santa Cruz Santa Cruz CA USA 95064 A 95064 USA
Citazione:
G.B. Silberstein, "Tumour-stromal interactions - Role of the stroma in mammary development", BREAST CA R, 3(4), 2001, pp. 218-223

Abstract

Mammary development depends on branching morphogenesis, namely the bifurcation and extension of ductal growth points (end buds) and secretory lobulesinto a more or less fatty stroma. Because breast carcinomas are overwhelmingly ductal in origin, this review focuses on stromal influences guiding postnatal ductal development and there is only the briefest account of the role of embryonic stroma (mesenchyme). The stroma as the necessary target forendocrine mammogens and the source of stimulatory growth factors is described and the importance of mammary epithelium-induced modifications of the periductal stroma is emphasized. Evidence is presented that if they are to grow, end buds must condition proximal fatty stroma by recruiting white blood cells as well as inducing stromal cell division and, possibly, estrogen receptors. The induction of a fibrous stromal tunic around the end bud is described and its likely role as a complex ductal morphogen is discussed; a possible role in growth inhibition is also considered. Although the signals governing fibrotic induction, ductal morphogenesis, and growth inhibition are unknown, a role for transforming growth factor-P is highly likely and isdiscussed. Finally, a need for new conceptual and experimental approaches to understanding stromal-epithelial signaling is discussed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 01:52:06