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Titolo:
Neurotoxicity and molecular effects of methylmercury
Autore:
Castoldi, AF; Coccini, T; Ceccatelli, S; Manzo, L;
Indirizzi:
Salvatore Maugeri Fdn, Div Toxicol, I-27100 Pavia, Italy Salvatore MaugeriFdn Pavia Italy I-27100 Toxicol, I-27100 Pavia, Italy Univ Pavia, I-27100 Pavia, Italy Univ Pavia Pavia Italy I-27100Univ Pavia, I-27100 Pavia, Italy Karolinska Inst, Stockholm, Sweden Karolinska Inst Stockholm SwedenKarolinska Inst, Stockholm, Sweden
Titolo Testata:
BRAIN RESEARCH BULLETIN
fascicolo: 2, volume: 55, anno: 2001,
pagine: 197 - 203
SICI:
0361-9230(20010515)55:2<197:NAMEOM>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
EMBRYONAL CARCINOMA-CELLS; CEREBELLAR GRANULE CELLS; SEYCHELLES CHILD-DEVELOPMENT; OXYGEN SPECIES FORMATION; METHYL MERCURY; RAT-BRAIN; FETAL METHYLMERCURY; INTRACELLULAR CA2+; PRENATAL EXPOSURE; REDUCTIVE RESERVE;
Keywords:
apoptosis; microtubules; calcium; oxidative stress; excitotoxicity; neurotransmission;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
78
Recensione:
Indirizzi per estratti:
Indirizzo: Castoldi, AF Salvatore Maugeri Fdn, Div Toxicol, Via Ferrata 8, I-27100 Pavia, Italy Salvatore Maugeri Fdn Via Ferrata 8 Pavia Italy I-27100 taly
Citazione:
A.F. Castoldi et al., "Neurotoxicity and molecular effects of methylmercury", BRAIN RES B, 55(2), 2001, pp. 197-203

Abstract

The neurotoxicity of high levels of methylmercury (MeHg) and the high susceptibility of the developing brain are well established both in humans and experimental animals. Prenatally poisoned children display a range of effects varying from severe cerebral palsy to subtle developmental delays. Stillunknown is the lowest dose that impairs neurodevelopment. The primary source of human exposure is the fish. The data obtained so far from epidemiological studies on fish-eating populations are not consistent. A reference dose of 0.1 mug MeHg/kg per day has been established by the U.S. EnvironmentalProtection Agency based on a study on Iraq! children exposed to MeHg in utero. However, these exposures occurred at high level for a limited period of time, and consequently were not typical of lower chronic exposure levels associated with fish consumption. Major obstacles for estimation of a threshold dose for MeHg include the delayed appearance of the neurodevelopmentaleffects following prenatal exposure and limited knowledge of cellular and molecular processes underlying these neurological changes. In this respect,a strategy which aims at identifying sensitive molecular targets of MeHg at environmentally relevant levels may prove particularly useful to risk assessment. Here some examples of MeHg molecular effects occurring at low doses/concentrations are presented. (C) 2001 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 06:13:46