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Titolo:
Characterization of the phosphatidylserine-exposing subpopulation of sickle cells
Autore:
de Jong, K; Larkin, SK; Styles, LA; Bookchin, RM; Kuypers, FA;
Indirizzi:
Childrens Hosp Oakland, Res Inst, Oakland, CA 94609 USA Childrens Hosp Oakland Oakland CA USA 94609 s Inst, Oakland, CA 94609 USA Albert Einstein Coll Med, Dept Med, Bronx, NY 10467 USA Albert Einstein Coll Med Bronx NY USA 10467 Dept Med, Bronx, NY 10467 USA
Titolo Testata:
BLOOD
fascicolo: 3, volume: 98, anno: 2001,
pagine: 860 - 867
SICI:
0006-4971(20010801)98:3<860:COTPSO>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
MEMBRANE PHOSPHOLIPID ASYMMETRY; RED-BLOOD-CELLS; ERYTHROCYTE-MEMBRANE; OXIDATIVE DAMAGE; DEOXYGENATION; EXPOSURE; ANEMIA; THALASSEMIA; POPULATION; CALCIUM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: de Jong, K Childrens Hosp Oakland, Res Inst, 5700 Martin Luther King Jr Way, Oakland,CA 94609 USA Childrens Hosp Oakland 5700 Martin Luther King Jr Way Oakland CA USA 94609
Citazione:
K. de Jong et al., "Characterization of the phosphatidylserine-exposing subpopulation of sickle cells", BLOOD, 98(3), 2001, pp. 860-867

Abstract

Phosphatidylserine (PS), exclusively present in the inner monolayer of thenormal red blood cell (RBC) membrane, is exposed in subpopulations of sickle cells. PS-exposing RBCs were found predominantly among the densest and the very light sickle cells. Within the light RBC fraction, PS exposure was found on reticulocytes, transferrin receptor-expressing reticulocytes, and mature RBCs. The last subset contained low-density valinomycin-resistant RBCs, previously shown to have high Na+ and low K+ content. This subpopulation contained the highest percentage of PS-exposing cells. The PS-exposing sickle cells did not show the sustained high cytosolic Ca++ levels that have been shown to activate scramblase, activity. Data from this study indicate that PS exposure can occur at different stages in the life of the sickle RBC and that It correlates with the loss of aminophospholipid translocase activity, the only common denominator of the PS-exposing cells. The additionalrequirement of scramblase activation may occur during transient increases In cytosollc Ca++. (C) 2001 by The American Society of Hematology.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/09/20 alle ore 00:30:52