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Titolo:
Type I interferons in combination with bacterial stimuli induce apoptosis of monocyte-derived dendritic cells
Autore:
Lehner, M; Felzmann, T; Clodi, K; Holter, W;
Indirizzi:
St Anna Childrens Hosp, Childrens Canc Res Inst, A-1090 Vienna, Austria StAnna Childrens Hosp Vienna Austria A-1090 nst, A-1090 Vienna, Austria
Titolo Testata:
BLOOD
fascicolo: 3, volume: 98, anno: 2001,
pagine: 736 - 742
SICI:
0006-4971(20010801)98:3<736:TIIICW>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
NITRIC-OXIDE SYNTHASE; TUMOR-NECROSIS-FACTOR; BLOOD MONONUCLEAR-CELLS; IFN-ALPHA; PERITONEAL-MACROPHAGES; MESSENGER-RNA; IL-12 PRODUCTION; HIV-1 INFECTION; T-CELLS; EXPRESSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Holter, W Childrens Canc Res Inst, Kinderspitalgasse 6, A-1090 Vienna, Austria Childrens Canc Res Inst Kinderspitalgasse 6 Vienna Austria A-1090
Citazione:
M. Lehner et al., "Type I interferons in combination with bacterial stimuli induce apoptosis of monocyte-derived dendritic cells", BLOOD, 98(3), 2001, pp. 736-742

Abstract

Both type I interferons (IFNs) as well as lipopolysaccharide (LIPS) individually compromise selected monocytic or dendritic cell (DC) functions. Thisstudy investigates the influence of these agents on the differentiation and the regulation of cell death of monocyte-derived DCs generated in the presence of granulocyte-macrophage colony-stimulating factor plus interleukin-4 (IL-4). It is reported that excessive apoptosis occurred rapidly in monocyte-derived DC cultures, if IFN-alpha or IFN-beta was added in combination with LIPS or lipoteichoic acid (LTA). The small fraction of cells survivingin such cultures displayed a mature DC phenotype with expression of CD83, CD80, and CD86. IL-10 was found in the supernatants of monocyte-derived DC cultures, if supplemented with LIPS or IFN-alpha plus LIPS but not in control cultures. When monocytederived DCs were generated in the presence of IFN-alpha without LIPS, these cells displayed an immature DC phenotype with a reduction of cell recovery but no overt apoptosis. However, the addition ofLIPS, LTA, LIPS plus IFN-gamma, or tumor necrosis factor alpha (TNF-alpha)plus prostaglandin E2 to such cells again resulted In the rapid induction of apoptosis in the majority of cells, together with a reduced production of IL-12 p70 and TNF-alpha. Together, these data indicate an exquisite sensitivity of monocyte-derived DCs to activation-induced cell death If generated In the presence of IFN-alpha, indicating the existence of an Important mechanism of Immunosuppression caused by IFN-alpha -inducing agents, such as viral or bacterial stimuli. (C) 2001 by The American Society of Hematology.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/10/20 alle ore 09:59:31